Introduction：Basic information about CAS 756525-98-1|Mal-amido-PEG2-C2-acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mal-amido-PEG2-C2-acid |
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| CAS Number | 756525-98-1 | Molecular Weight | 328.318 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 617.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C14H20N2O7 | Melting Point | / |
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| MSDS | / | Flash Point | 327.2±31.5 °C |
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Names
| Name | MAL-PEG2-COOH |
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| Synonym | More Synonyms |
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Mal-amido-PEG2-C2-acid BiologicalActivity
| Description | Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 617.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C14H20N2O7 |
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| Molecular Weight | 328.318 |
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| Flash Point | 327.2±31.5 °C |
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| Exact Mass | 328.127045 |
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| LogP | -1.54 |
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| Vapour Pressure | 0.0±3.8 mmHg at 25°C |
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| Index of Refraction | 1.530 |
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| InChIKey | GBPJQBDDYXDSNH-UHFFFAOYSA-N |
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| SMILES | O=C(O)CCOCCOCCNC(=O)CCN1C(=O)C=CC1=O |
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| Storage condition | 2-8°C |
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Synonyms
| Propanoic acid, 3-[2-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]- |
| 3-[2-(2-{[3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]amino}ethoxy)ethoxy]propanoic acid |
