Introduction：Basic information about CAS 1137648-52-2|Ilexhainanoside D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ilexhainanoside D |
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| CAS Number | 1137648-52-2 | Molecular Weight | 664.83 |
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| Density | 1.35±0.1 g/cm3(Predicted) | Boiling Point | 788.1±60.0 °C(Predicted) |
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| Molecular Formula | C36H56O11 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
Ilexhainanoside D BiologicalActivity
| Description | Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect[1]. |
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| Related Catalog | Signaling Pathways >>Others >>Others |
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| In Vivo | The combination of Ilexhainanoside D and Ilexsaponin A (60, 120 or 240 mg/kg; for 8 weeks) treatment significantly reduces the severity of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in a dose-dependent manner. The combination of Ilexhainanoside D and Ilexsaponin A treatment decreases the ratio of Firmicutes/Bacteroidetes, reduces the relative abundance of Desulfovibrio and increases the relative abundance of Akkermansia. The intestinal barrier is improved as evidenced by the upregulation of the expression of zonula occludens-1 (ZO-1) and occludin in the ileum. The combination of Ilexhainanoside D and Ilexsaponin A treatment reduces the entry of LPS into the circulation and decreases the hepatic gene expression levels of proinflammatory cytokines[1]. |
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| References | [1]. Zhao W, et al. The combination of Ilexhainanoside D and ilexsaponin A1 reduces liver inflammation and improves intestinal barrier function in mice with high-fat diet-induced non-alcoholic fatty liver disease. Phytomedicine. 2019 Jul 26;63:153039. |
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Chemical & Physical Properties
| Density | 1.35±0.1 g/cm3(Predicted) |
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| Boiling Point | 788.1±60.0 °C(Predicted) |
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| Molecular Formula | C36H56O11 |
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| Molecular Weight | 664.83 |
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| InChIKey | PWXPWSCNXVCOCA-UHFFFAOYSA-N |
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| SMILES | CC1(C)CCC2(C(=O)OC3OC(CO)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C(=O)O)C5CCC43C)C2C1O |
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