Introduction：Basic information about CAS 1123837-84-2|Sitravatinib (MGCD516), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sitravatinib (MGCD516) |
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| CAS Number | 1123837-84-2 | Molecular Weight | 629.676 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 833.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C33H29F2N5O4S | Melting Point | / |
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| MSDS | / | Flash Point | 457.9±34.3 °C |
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Names
| Name | Sitravatinib |
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| Synonym | More Synonyms |
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Sitravatinib (MGCD516) BiologicalActivity
| Description | Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth with IC50 of 3980 nmol/Lin vitro: MGCD516 is superior to other multi-kinase inhibitors in inhibiting cell proliferation, RTK phosphorylation, and phosphorylation of downstream effectors. MGCD516 is unique in a way that it has broad spectrum activity against many RTKs including c-Met, c-Kit, Axl, PDGFR, and Eph receptors that are known to play a role in driving sarcoma cell growthIn vivo: MGCD516 induces significant tumor growth suppression than imatinib and crizotinib. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>c-KitResearch Areas >>Cancer |
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| References | [1]. Patwardhan PP et al. Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma. Oncotarget, 2016 Jan 26;7(4):4093-109. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 833.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C33H29F2N5O4S |
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| Molecular Weight | 629.676 |
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| Flash Point | 457.9±34.3 °C |
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| Exact Mass | 629.190857 |
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| LogP | 6.00 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.685 |
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| InChIKey | WLAVZAAODLTUSW-UHFFFAOYSA-N |
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| SMILES | COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)cc4F)c3s2)nc1 |
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| Storage condition | -20℃ |
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Synonyms
| UNII:CWG62Q1VTB |
| CWG62Q1VTB |
| MGCD516 |
| Sitravatinib |
| 1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)- |
| N-(3-Fluoro-4-{[2-(5-{[(2-methoxyethyl)amino]methyl}-2-pyridinyl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
