CAS 1443530-05-9|Rogaratinib
Introduction：Basic information about CAS 1443530-05-9|Rogaratinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rogaratinib | ||
|---|---|---|---|
| CAS Number | 1443530-05-9 | Molecular Weight | 466.556 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C23H26N6O3S | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | Rogaratinib |
|---|---|
| Synonym | More Synonyms |
Rogaratinib BiologicalActivity
| Description | Rogaratinib is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor. |
|---|---|
| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>FGFRResearch Areas >>Cancer |
| Target | FGFR1 FGFR2 FGFR3 FGFR4 |
| In Vitro | Of the 24 cell lines, 2 FGFR1-amplified lung cancer (LC) cell lines, H1581 and DMS114, show extreme sensitivity to Rogaratinib (BAY1163877) (GI50 values ranging from 36 to 244 nM). Treatment with Rogaratinib results in a significant decrease in colonies formed by H1581P cells, but not by H1581AR and BR cells. Ectopic expression of Met significantly induces resistance to Rogaratinib in MTT assays. Met overexpression induces activation of downstream extracellular signal-regulated kinase 1/2 (ERK1/2) and AKT, which cannot be abrogated by Rogaratinib treatment[1]. |
| Cell Assay | Cells (3000 cells/well) are seeded on 96-well plates at 37°C. After overnight incubation, the cells are treated with Rogaratinib for 72 h. Then, MTT reagent [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide] is added to each well and incubated for 4 h at 37°C. MTT solubilization solution/stop mix is added to each well, mixed, and the plates are incubated overnight at 37°C. After measuring the absorbance at 570 nm, the data are graphically displayed[1]. |
| References | [1]. Kim SM, et al. Activation of the Met kinase confers acquired drug resistance in FGFR-targeted lung cancer therapy. Oncogenesis. 2016 Jul 18;5(7):e241. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H26N6O3S |
| Molecular Weight | 466.556 |
| Exact Mass | 466.178711 |
| LogP | 0.98 |
| Index of Refraction | 1.731 |
| InChIKey | HNLRRJSKGXOYNO-UHFFFAOYSA-N |
| SMILES | COCc1c(-c2cc3cc(C)cc(OC)c3s2)c2c(N)ncnn2c1CN1CCNC(=O)C1 |
| Storage condition | 2-8℃ |
Synonyms
| 4-{[4-Amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}-2-piperazinone |
| 10372 |
| 2-Piperazinone, 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methylbenzo[b]thien-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]- |
| 98BSN6N516 |
| Rogaratinib |
| UNII:98BSN6N516 |
