CAS 1488363-78-5|Adomeglivant

Introduction：Basic information about CAS 1488363-78-5|Adomeglivant, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Adomeglivant BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Adomeglivant
CAS Number	1488363-78-5	Molecular Weight	555.628
Density	1.2±0.1 g/cm3	Boiling Point	656.7±55.0 °C at 760 mmHg
Molecular Formula	C₃₂H₃₆F₃NO₄	Melting Point	/
MSDS	/	Flash Point	350.9±31.5 °C

Names

Name	Adomeglivant
Synonym	More Synonyms

Adomeglivant BiologicalActivity

Description	Adomeglivant is a potent and selective glucagon receptor antagonist that is used in clinical trial for type 2 diabetes mellitus.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Glucagon ReceptorResearch Areas >>Metabolic Disease
References	[1]. Li Y et al. Efficient Synthesis of β-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols. Org Lett. 2015 May 1;17(9):2186-9. [2]. Kazda CM et al. Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies. Diabetes Care. 2016 Jul;39(7):1241-9.

Description

Adomeglivant is a potent and selective glucagon receptor antagonist that is used in clinical trial for type 2 diabetes mellitus.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Glucagon ReceptorResearch Areas >>Metabolic Disease

References

[1]. Li Y et al. Efficient Synthesis of β-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols. Org Lett. 2015 May 1;17(9):2186-9.

[2]. Kazda CM et al. Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies. Diabetes Care. 2016 Jul;39(7):1241-9.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	656.7±55.0 °C at 760 mmHg
Molecular Formula	C₃₂H₃₆F₃NO₄
Molecular Weight	555.628
Flash Point	350.9±31.5 °C
Exact Mass	555.259644
LogP	7.53
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.542
InChIKey	FASLTMSUPQDLIB-MHZLTWQESA-N
SMILES	Cc1cc(OC(CCC(F)(F)F)c2ccc(C(=O)NCCC(=O)O)cc2)cc(C)c1-c1ccc(C(C)(C)C)cc1
Storage condition	2-8℃

Synonyms

3-(4-{(1S)-1-[(4'-tert-butyl-2,6-dimethylbiphenyl-4-yl)oxy]-4,4,4-trifluorobutyl}benzamido)propanoic acid

adomeglivant

UNII:74Z5ZL2KVG

74Z5ZL2KVG

β-Alanine, N-[4-[(1S)-1-[[4'-(1,1-dimethylethyl)-2,6-dimethyl[1,1'-biphenyl]-4-yl]oxy]-4,4,4-trifluorobutyl]benzoyl]-

N-{4-[(1S)-1-{[2,6-Dimethyl-4'-(2-methyl-2-propanyl)-4-biphenylyl]oxy}-4,4,4-trifluorobutyl]benzoyl}-β-alanine

LY2409021

UNII-74Z5ZL2KVG

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