Introduction：Basic information about CAS 209219-38-5|Nastorazepide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nastorazepide |
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| CAS Number | 209219-38-5 | Molecular Weight | 520.620 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 742.8±60.0 °C at 760 mmHg |
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| Molecular Formula | C29H36N4O5 | Melting Point | / |
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| MSDS | / | Flash Point | 403.0±32.9 °C |
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Names
| Name | Nastorazepide |
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| Synonym | More Synonyms |
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Nastorazepide BiologicalActivity
| Description | Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Target：CCK-2in vitro: Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent. in vivo: Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Cholecystokinin ReceptorResearch Areas >>Cancer |
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| References | [1]. Kato H, et al. CCK-2/gastrin receptor signaling pathway is significant for gemcitabine-induced gene expression of VEGF in pancreatic carcinoma cells. Life Sci. 2011 Oct 24;89(17-18):603-8. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 742.8±60.0 °C at 760 mmHg |
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| Molecular Formula | C29H36N4O5 |
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| Molecular Weight | 520.620 |
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| Flash Point | 403.0±32.9 °C |
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| Exact Mass | 520.268555 |
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| LogP | 5.23 |
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| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
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| Index of Refraction | 1.631 |
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| InChIKey | VIJCCFFEBCOOIE-JOCHJYFZSA-N |
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| SMILES | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)CN(C2CCCCC2)c2ccccc21 |
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| Storage condition | 2-8℃ |
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Synonyms
| R22TMY97SG |
| Benzoic acid, 3-[[[[(3R)-5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-2,3,4,5-tetrahydro-2-oxo-1H-1,5-benzodiazepin-3-yl]amino]carbonyl]amino]- |
| 3-({[(3R)-5-Cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]carbamoyl}amino)benzoic acid |
| nastorazepide |
