Introduction：Basic information about CAS 836683-15-9|Acumapimod, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Acumapimod |
|---|
| CAS Number | 836683-15-9 | Molecular Weight | 385.419 |
|---|
| Density | 1.4±0.1 g/cm3 | Boiling Point | 675.6±55.0 °C at 760 mmHg |
|---|
| Molecular Formula | C22H19N5O2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 362.4±31.5 °C |
|---|
Names
| Name | Acumapimod |
|---|
| Synonym | More Synonyms |
|---|
Acumapimod BiologicalActivity
| Description | Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α. |
|---|
| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/Immunology |
|---|
| Target | IC50: less than 1 μM (p38α)[1] |
|---|
| In Vitro | Acumapimod is an inhibitor of p38α with an IC50 value of less than 1 μM. |
|---|
| In Vivo | BCT197 is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions, including chronic obstructive pulmonary disease (COPD). Intermittent short-term dosing of BCT197 (75 mg on days 1 and 6) shows a marked improvement in lung function in COPD patients[2]. |
|---|
| References | [1]. Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. [2]. De Buck S, et al. Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700. |
|---|
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|
| Boiling Point | 675.6±55.0 °C at 760 mmHg |
|---|
| Molecular Formula | C22H19N5O2 |
|---|
| Molecular Weight | 385.419 |
|---|
| Flash Point | 362.4±31.5 °C |
|---|
| Exact Mass | 385.153870 |
|---|
| LogP | 2.57 |
|---|
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
|---|
| Index of Refraction | 1.708 |
|---|
| InChIKey | VGUSQKZDZHAAEE-UHFFFAOYSA-N |
|---|
| SMILES | Cc1ccc(C(=O)NC2CC2)cc1-n1ncc(C(=O)c2cccc(C#N)c2)c1N |
|---|
| Storage condition | 2-8℃ |
|---|
Synonyms
| Benzamide, 3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl- |
| 3-[5-Amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide |
| acumapimod |
