Introduction：Basic information about CAS 99119-72-9|Kushenol E, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kushenol E |
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| CAS Number | 99119-72-9 | Molecular Weight | 424.486 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 674.8±55.0 °C at 760 mmHg |
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| Molecular Formula | C25H28O6 | Melting Point | / |
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| MSDS | / | Flash Point | 230.7±25.0 °C |
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Names
| Name | Kushenol E |
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| Synonym | More Synonyms |
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Kushenol E BiologicalActivity
| Description | Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| References | [1]. Kwon M, et al. Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1481-1488. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 674.8±55.0 °C at 760 mmHg |
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| Molecular Formula | C25H28O6 |
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| Molecular Weight | 424.486 |
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| Flash Point | 230.7±25.0 °C |
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| Exact Mass | 424.188599 |
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| LogP | 6.66 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.632 |
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| InChIKey | ZTEYEFPSJPSRRA-NRFANRHFSA-N |
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| SMILES | CC(C)=CCc1c(O)c(CC=C(C)C)c2c(c1O)C(=O)CC(c1ccc(O)cc1O)O2 |
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Synonyms
| 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-6,8-bis(3-methyl-2-buten-1-yl)-, (2S)- |
| (2S)-2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one |
| 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-6,8-bis(3-methyl-2-butenyl)-, (S)- |
