CAS 145017-83-0|ω-Agatoxin IVa trifluoroacetate salt
| Common Name | ω-Agatoxin IVa trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 145017-83-0 | Molecular Weight | / |
| Density | / | Boiling Point | / |
| Molecular Formula | C217H360N68O60S10 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | ω-Agatoxin IVA |
|---|
ω-Agatoxin IVa trifluoroacetate salt BiologicalActivity
| Description | ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels[1][2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Neurological Disease |
| Target | IC50: 2 nM (P-type Ca2+ channels), 90 nM (Q-type Ca2+ channels)[1] |
| References | [1]. T Teramoto, et al. A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons. Brain Res. 1997 May 9;756(1-2):225-30. [2]. M Kimura, et al. Involvement of P-type calcium channels in high potassium-elicited release of neurotransmitters from rat brain slices. Neuroscience. 1995 Jun;66(3):609-15. |
Chemical & Physical Properties
| Molecular Formula | C217H360N68O60S10 |
|---|---|
| InChIKey | NVVFOMZVLALQKT-UHFFFAOYSA-N |
| SMILES | CCC(C)C1NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(N)CCCCN)CSSCC2NC(=O)C3CSSCC(C(=O)NC(CCCCN)C(=O)N4CCCC4C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)C(C)CC)NC(=O)C(CCC(=O)O)NC(=O)C4CSSCC(NC(=O)C(C(C)CC)NC(=O)C(CSSCC(NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(Cc5ccc(O)cc5)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(C)NC1=O)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c5ccccc15)C(=O)NCC(=O)NCC(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)N3)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CCCNC(=N)N)NC2=O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NCC(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)N4 |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles3
More Articles| P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature 355 , 827-829, (1992) Voltage-dependent calcium channels mediate calcium entry into neurons, which is crucial for many processes in the brain including synaptic transmission, dendritic spiking, gene expression and cell dea... | |
| P-type calcium channels in rat central and peripheral neurons. Neuron 9 , 85-95, (1992) The peptide toxin omega-Aga-IVA blocked P-type Ca2+ channel current in rat Purkinje neurons (KD approximately 2 nM) but had no effect on identified T-type, L-type, or N-type currents in a variety of c... | |
| Calcium channels coupled to glutamate release identified by omega-Aga-IVA. Science 258 , 310-313, (1992) Presynaptic calcium channels are crucial elements of neuronal excitation-secretion coupling. In mammalian brain, they have been difficult to characterize because most presynaptic terminals are too sma... |
