Introduction：Basic information about CAS 1191995-00-2|Dorzagliatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dorzagliatin |
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| CAS Number | 1191995-00-2 | Molecular Weight | 462.927 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 761.7±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H27ClN4O5 | Melting Point | / |
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| MSDS | / | Flash Point | 414.5±32.9 °C |
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Names
| Name | dorzagliatin |
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| Synonym | More Synonyms |
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Dorzagliatin BiologicalActivity
| Description | Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>GlucokinaseResearch Areas >>Metabolic Disease |
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| Target | Glucokinase[1] |
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| In Vivo | Dorzagliatin (low-dose 10 mg/kg, and high-dose 30 mg/kg; administered intragastrically; daily 8:00 AM for one month) exerts a glucose-lowering effect on the glucose levels in diabetic rats[2. Animal Model: Male Sprague-Dawley (SD) rats (aged approximately 6–8 weeks and weighing 200-230 g)[2 Dosage: Low-dose (10 mg/kg), and high-dose (30 mg/kg) Administration: Administered intragastrically (i.g.); daily (8:00 AM) for one month Result: Exerted a glucose-lowering effect on the glucose levels. |
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| References | [1]. Zhu XX, et al. Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection. Diabetes Obes Metab. 2018 Sep;20(9):2113-2120. [2]. Wang P, et al. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. J Diabetes Res. 2017;2017:5812607. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 761.7±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H27ClN4O5 |
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| Molecular Weight | 462.927 |
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| Flash Point | 414.5±32.9 °C |
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| Exact Mass | 462.166992 |
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| LogP | 2.78 |
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| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
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| Index of Refraction | 1.631 |
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| InChIKey | HMUMWSORCUWQJO-QAPCUYQASA-N |
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| SMILES | CC(C)CC(C(=O)Nc1ccn(CC(O)CO)n1)N1CC(Oc2ccccc2Cl)=CC1=O |
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Synonyms
| (2S)-2-[4-(2-Chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide |
| X59W6980E8 |
| 1H-Pyrrole-1-acetamide, 4-(2-chlorophenoxy)-N-[1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl]-2,5-dihydro-α-(2-methylpropyl)-2-oxo-, (αS)- |
| dorzagliatin |
| 10511 |
