Introduction：Basic information about CAS 158732-55-9|Escin IIa, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Escin IIa |
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| CAS Number | 158732-55-9 | Molecular Weight | 1101.231 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 1111.9±65.0 °C at 760 mmHg |
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| Molecular Formula | C54H84O23 | Melting Point | / |
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| MSDS | / | Flash Point | 305.5±27.8 °C |
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Names
| Name | 82XHO27XQ8 |
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| Synonym | More Synonyms |
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Escin IIa BiologicalActivity
| Description | Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vivo | Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest[1]. Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions[2]. Animal Model: Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)[1] Dosage: 10-50 mg/kg Administration: p.o. Result: Showed a potent protective effect against ethanol-induced gastric lesions in rats. |
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| References | [1]. Matsuda H, et al. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull. 1997;20(10):1092-1095. [2]. Matsuda H, et al. Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur J Pharmacol. 1999;373(1):63-70. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 1111.9±65.0 °C at 760 mmHg |
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| Molecular Formula | C54H84O23 |
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| Molecular Weight | 1101.231 |
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| Flash Point | 305.5±27.8 °C |
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| Exact Mass | 1100.540283 |
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| LogP | 4.87 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.624 |
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| InChIKey | MLLNRQWNTKNRGQ-UHFFFAOYSA-N |
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| SMILES | CC=C(C)C(=O)OC1C(OC(C)=O)C2(CO)C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(C(=O)O)C(OC7OC(CO)C(O)C(O)C7O)C(O)C6OC6OCC(O)C(O)C6O)C(C)(CO)C5CCC43C)C2CC1(C)C |
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Synonyms
| (3β,16α,21β,22α)-22-Acetoxy-16,24,28-trihydroxy-21-{[(2E)-2-methyl-2-butenoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->4)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosiduronic 
acid |
| 2-butenoic acid, 2-methyl-, (3β,16α,21β,22α)-22-(acetyloxy)-3-[[O-β-D-glucopyranosyl-(1->4)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranuronosyl]oxy]-16,24,28-trihydroxyolean-12-en-21-yl ester, (2E)- |
| 82XHO27XQ8 |
| MFCD10566614 |
| (3β,16α,21β,22α)-22-Acetoxy-16,24,28-trihydroxy-21-{[(2E)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->4)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosiduronic acid |
| 2-Butenoic acid, 2-methyl-, (3β,16α,21β,22α)-22-(acetyloxy)-3-[[O-β-D-glucopyranosyl-(1->4)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranuronosyl]oxy]-16,24,28-trihydroxyolean-12- 
en-21-yl ester, (2E)- |
