Introduction：Basic information about CAS 1593673-23-4|Etripamil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Etripamil |
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| CAS Number | 1593673-23-4 | Molecular Weight | 452.59 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 593.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C27H36N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | 312.9±30.1 °C |
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Names
| Name | Etripamil |
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| Synonym | More Synonyms |
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Etripamil BiologicalActivity
| Description | Etripamil (MSP-2017) is a short-acting L-type calcium-channel antagonist with a rapid onset of action designed for intranasal administration, used to treat Paroxysmal Supraventricular Tachycardia (PSVT). Etripamil (MSP-2017) slows atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells[1][2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease |
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| Target | L-type calcium channel |
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| References | [1]. Stambler BS, et al. Etripamil Nasal Spray for Rapid Conversion of Supraventricular Tachycardia to Sinus Rhythm. J Am Coll Cardiol. 2018 Jul 31;72(5):489-497. [2]. Milestone Pharmaceuticals Announces USAN Approval of Generic Name “Etripamil” for its Phase 2 Clinical Development Product for the Treatment of Paroxysmal Supraventricular Tachycardia. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 593.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C27H36N2O4 |
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| Molecular Weight | 452.59 |
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| Flash Point | 312.9±30.1 °C |
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| Exact Mass | 452.267517 |
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| LogP | 4.14 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.534 |
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| InChIKey | VAZNEHLGJGSQEL-MHZLTWQESA-N |
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| SMILES | COC(=O)c1cccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)c1 |
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Synonyms
| MSP-2017 |
| UNII:S82A18Y42P |
| (-)-MSP-2017 |
| Methyl 3-(2-{[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl](methyl)amino}ethyl)benzoate |
| Benzoic acid, 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]-, methyl ester |
| Etripamil |
