CAS 1414854-42-4|Verosudil(AR-12286)
Introduction：Basic information about CAS 1414854-42-4|Verosudil(AR-12286), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Verosudil(AR-12286) | ||
|---|---|---|---|
| CAS Number | 1414854-42-4 | Molecular Weight | 327.401 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 625.5±55.0 °C at 760 mmHg |
| Molecular Formula | C17H17N3O2S | Melting Point | / |
| MSDS | / | Flash Point | 332.1±31.5 °C |
Names
| Name | verosudil |
|---|---|
| Synonym | More Synonyms |
Verosudil(AR-12286) BiologicalActivity
| Description | Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>ROCKResearch Areas >>Neurological DiseaseSignaling Pathways >>Stem Cell/Wnt >>ROCKSignaling Pathways >>TGF-beta/Smad >>ROCK |
| Target | ROCK1:2 nM (Ki) ROCK2:2 nM (Ki) PKA:69 nM (Ki) MRCKA:28 nM (Ki) CAM2A:5855 nM (Ki) PKC theta:9322 nM (Ki) |
| References | [1]. Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51. [2]. Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 625.5±55.0 °C at 760 mmHg |
| Molecular Formula | C17H17N3O2S |
| Molecular Weight | 327.401 |
| Flash Point | 332.1±31.5 °C |
| Exact Mass | 327.104156 |
| LogP | 0.84 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.666 |
| InChIKey | VDYRZXYYQMMFJW-UHFFFAOYSA-N |
| SMILES | CN(C)C(C(=O)Nc1ccc2c(=O)[nH]ccc2c1)c1ccsc1 |
Synonyms
| verosudil |
| UNII:MAF34143WM |
| 2-(Dimethylamino)-N-(1-oxo-1,2-dihydro-6-isoquinolinyl)-2-(3-thienyl)acetamide |
| 3-Thiopheneacetamide, N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-α-(dimethylamino)- |
| UNII: MAF34143WM |
| AR-12286 |
| MAF34143WM |
