CAS 1436861-97-0|Zidebactam

Introduction：Basic information about CAS 1436861-97-0|Zidebactam, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Zidebactam BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Zidebactam
CAS Number	1436861-97-0	Molecular Weight	391.40
Density	1.6±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₃H₂₁N₅O₇S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	zidebactam
Synonym	More Synonyms

Zidebactam BiologicalActivity

Description	Zidebactam (WCK-5107) is a potent β-lactamase inhibitor[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL[2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial
Target	IC50: 0.26 μg/mL (P. aeruginosa PAO1 PBP2)[2]
In Vitro	Zidebactam (WCK-5107) inhibits WT Enterobacteriaceae with a MIC50 of 0.25 mg/L. Zidebactam alone exhibits variable activity when tested against E. coli (MIC50/90 0.12/0.12 mg/L) and Enterobacter spp. (MIC50/90 0.12/0.25 mg/L)[1].
References	[1]. Sader HS, et al. WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1696-1703. [2]. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6).

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₃H₂₁N₅O₇S
Molecular Weight	391.40
Exact Mass	391.116180
LogP	-3.01
Index of Refraction	1.653
InChIKey	YCZPXRQPDCXTIO-BBBLOLIVSA-N
SMILES	O=C(NNC(=O)C1CCC2CN1C(=O)N2OS(=O)(=O)O)C1CCCNC1
Storage condition	2-8℃

Synonyms

zidebactam

1,6-Diazabicyclo[3.2.1]octane-2-carboxylic acid, 7-oxo-6-(sulfooxy)-, 2-[2-[(3R)-3-piperidinylcarbonyl]hydrazide], (2S,5R)-

YPM97423DB

(2S,5R)-7-Oxo-N'-[(3R)-3-piperidinylcarbonyl]-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide

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