Introduction：Basic information about CAS 1421866-48-9|Apimostinel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Apimostinel |
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| CAS Number | 1421866-48-9 | Molecular Weight | 503.591 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 878.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C25H37N5O6 | Melting Point | / |
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| MSDS | / | Flash Point | 485.2±34.3 °C |
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Names
| Name | apimostinel |
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| Synonym | More Synonyms |
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Apimostinel BiologicalActivity
| Description | Apimostinel is an oral NMDA receptor partial agonist. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>iGluRSignaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological Disease |
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| In Vitro | Apimostinel (NRX-1074) modulates the NMDA receptor in a similar fashion to GLYX-13, but has a synthetic modification to one of the amino acids, conferring increased potency and oral bioavailability[1]. |
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| In Vivo | In preclinical models the two compounds both appear to be highly efficacious across a number of CNS disorders[1]. |
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| References | [1]. Naurex's First Orally Active Molecule, NRX-1074, Demonstrates Statistically Significant Improvement in Depression Scores within 24 Hours in Phase 2 Study for Major Depressive Disorder. January 28, 2015. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 878.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C25H37N5O6 |
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| Molecular Weight | 503.591 |
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| Flash Point | 485.2±34.3 °C |
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| Exact Mass | 503.274384 |
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| LogP | 0.22 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.608 |
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| InChIKey | DVBUEXCIEIAXPM-PJUQSVSOSA-N |
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| SMILES | CC(O)C(N)C(=O)N1CCCC1C(=O)N1CCCC1(Cc1ccccc1)C(=O)NC(C(N)=O)C(C)O |
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| Storage condition | 2-8℃ |
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Synonyms
| NRX-1074 |
| L-Threonyl-L-prolyl-2-benzyl-L-prolyl-L-threoninamide |
| apimostinel |
| UNII:TTT1F11FZB |
| TTT1F11FZB |
| L-Threoninamide, L-threonyl-L-prolyl-2-(phenylmethyl)-L-prolyl- |
