CAS 1269726-67-1|Dapaconazole

Introduction：Basic information about CAS 1269726-67-1|Dapaconazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dapaconazole BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Dapaconazole
CAS Number	1269726-67-1	Molecular Weight	415.236
Density	1.4±0.1 g/cm3	Boiling Point	512.8±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₅Cl₂F₃N₂O	Melting Point	/
MSDS	/	Flash Point	263.9±30.1 °C

Names

Name	dapaconazole
Synonym	More Synonyms

Dapaconazole BiologicalActivity

Description	Dapaconazole, as an antifungal agent, inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 μM[1].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450
Target	Cytochrome P450 (CYP26):1.4 μM (IC50)
In Vitro	Dapaconazole inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 ± 0.3 μM[1].
In Vivo	Dapaconazole (20 mg/kg; p.o.) shows that the bioavailability is 97.3 %[1]. Animal Model: Male beagle dogs[1] Dosage: 20 mg/kg (Pharmacokinetic Analysis) Administration: P.o. Result: Showed that the bioavailability was 97.3 %.
References	[1]. Juliana SP, et al. Pharmacokinetics of Dapaconazole, A Novel Antifungal Agent, in Beagle Dogs and Inhibition of Cytochrome P450 Family 51. J Eur Acad Dermatol Venereol. 2018 Jun 10.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	512.8±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₅Cl₂F₃N₂O
Molecular Weight	415.236
Flash Point	263.9±30.1 °C
Exact Mass	414.051361
LogP	5.30
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.565
Storage condition	2-8°C

Synonyms

1-[2-(2,4-Dichlorophenyl)-2-{[4-(trifluoromethyl)benzyl]oxy}ethyl]-1H-imidazole

dapaconazole

H2976538CX

1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[[4-(trifluoromethyl)phenyl]methoxy]ethyl]-

UNII:H2976538CX

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