CAS 1210344-83-4|Ertugliflozin L-pyroglutamic acid
Introduction：Basic information about CAS 1210344-83-4|Ertugliflozin L-pyroglutamic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ertugliflozin L-pyroglutamic acid | ||
|---|---|---|---|
| CAS Number | 1210344-83-4 | Molecular Weight | 565.997 |
| Density | / | Boiling Point | / |
| Molecular Formula | C27H32ClNO10 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | Ertugliflozin L-pyroglutamic acid |
|---|---|
| Synonym | More Synonyms |
Ertugliflozin L-pyroglutamic acid BiologicalActivity
| Description | Ertugliflozin (PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. A drug for the treatment of type 2 diabetes mellitus[2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>SGLTResearch Areas >>Metabolic Disease |
| Target | IC50: 0.877 nM (h-SGLT2)[1]. |
| In Vitro | Ertugliflozin (PF-04971729) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro[3]. |
| In Vivo | Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats[3]. |
| References | [1]. Mascitti V, et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem. 2011 Apr 28;54(8):2952-60. [2]. Miao Z, et al. Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41(2):445-56. [3]. Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011 Sep;39(9):1609-19. |
Chemical & Physical Properties
| Molecular Formula | C27H32ClNO10 |
|---|---|
| Molecular Weight | 565.997 |
| Exact Mass | 565.171448 |
| Storage condition | 2-8℃ |
Synonyms
| MLU731K321 |
