CAS 145808-47-5|Margatoxin
| Common Name | Margatoxin | ||
|---|---|---|---|
| CAS Number | 145808-47-5 | Molecular Weight | / |
| Density | / | Boiling Point | / |
| Molecular Formula | C178H286N52O50S7 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Margatoxin |
|---|
Margatoxin BiologicalActivity
| Description | Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
| Target | Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1] |
| In Vivo | Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2]. |
| References | [1]. Bartok A, et al. Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels. Toxicon. 2014 Sep;87:6-16. [2]. Chen YC, et al. PreImplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids. Thromb Haemost. 2016 May 2;115(5):1010-24. |
Chemical & Physical Properties
| Molecular Formula | C178H286N52O50S7 |
|---|---|
| InChIKey | OVJBOPBBHWOWJI-UHFFFAOYSA-N |
| SMILES | CCC(C)C(NC(=O)C(N)C(C)O)C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC1CSSCC2NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)CNC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(Cc3ccccc3)NC(=O)C(CCC(N)=O)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C3CSSCC(C(=O)NC(Cc4ccc(O)cc4)C(=O)N4CCCC4C(=O)NC(Cc4cnc[nH]4)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CSSCC(NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CO)NC(=O)C(C(C)O)NC1=O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)N3)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(CCSC)NC2=O)C(C)C)C(C)CC |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles27
More Articles| Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes. Toxicology 289(1) , 11-8, (2011) Aconitine (ACO) is a highly toxic diterpenoid alkaloid and known to exert the immunomodulatory action. However, whether it has any effects on ion currents in immune cells remains unknown. The effects ... | |
| Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison. J. Phys. Chem. B 116(17) , 5132-40, (2012) The effect of the pore-blocking peptides charybdotoxin and margatoxin, both scorpion toxins, on currents through human voltage-gated hK(v)1.3 wild-type and hK(v)1.3_H399N mutant potassium channels was... | |
| Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra. Am. J. Physiol. Cell Physiol. 301(5) , C1186-200, (2011) We have characterized the native voltage-dependent K(+) (K(v)) current in rabbit urethral smooth muscle cells (RUSMC) and compared its pharmacological and biophysical properties with K(v)2.1 and K(v)2... |
