Introduction：Basic information about CAS 1214261-78-5|Zaurategrast ethyl ester sulfate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Zaurategrast ethyl ester sulfate |
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| CAS Number | 1214261-78-5 | Molecular Weight | 647.54 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C28H29BrN4O3.1/2H2O4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | L-Phenylalanine,N-(2-broMo-3-oxospiro[3.5]non-1-en-1-yl)-4-(2,7-naphthyridin-1-ylaMino)-,ethyl ester,sulfate (2:1) |
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| Synonym | More Synonyms |
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Zaurategrast ethyl ester sulfate BiologicalActivity
| Description | Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester prodrug of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Cytoskeleton >>Integrin |
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| Target | α4β1/α4β7 integrin[1] |
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| In Vitro | Zaurategrast ethyl ester sulfate (CDP323 sulfate), an ethyl ester prodrug of CT7758, shows some improvements in increasing mass transfer[1]. |
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| References | [1]. Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91. [2]. Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12(13-14):569-76. |
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Chemical & Physical Properties
| Molecular Formula | C28H29BrN4O3.1/2H2O4S |
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| Molecular Weight | 647.54 |
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| InChIKey | YAMQWVIKICWIKQ-FTBISJDPSA-N |
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| SMILES | CCOC(=O)C(Cc1ccc(Nc2nccc3ccncc23)cc1)NC1=C(Br)C(=O)C12CCCCC2.O=S(=O)(O)O |
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| Storage condition | 2-8℃ |
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Synonyms
| Zaurategrast ethyl ester sulfate |
