CAS 1420043-61-3|TolfenaMic acid-13C6

Introduction：Basic information about CAS 1420043-61-3|TolfenaMic acid-13C6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. TolfenaMic acid-13C6 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	TolfenaMic acid-13C6
CAS Number	1420043-61-3	Molecular Weight	267.659
Density	1.3±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₈₁₃C₆H₁₂ClNO₂	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS06	Signal Word	Danger

Names

Name	TolfenaMic acid-13C6
Synonym	More Synonyms

TolfenaMic acid-13C6 BiologicalActivity

Description	Tolfenamic acid-13C6 is the 13C6 labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
Related Catalog	Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Kay-Mugford P, et al. In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs. Am J Vet Res. 2000 Jul;61(7):802-10. [3]. Maliakal P, et al. Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats. Invest New Drugs. 2012 Jun;30(3):853-61. [4]. Sankpal UT, et al. Tolfenamic acid-induced alterations in genes and pathways in pancreatic cancer cells. Oncotarget. 2017 Feb 28;8(9):14593-14603

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Molecular Formula	C₈₁₃C₆H₁₂ClNO₂
Molecular Weight	267.659
Exact Mass	267.075775
Index of Refraction	1.658
InChIKey	YEZNLOUZAIOMLT-CDLMHYHCSA-N
SMILES	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Hazard Codes	Xn
Risk Phrases	22
RIDADR	UN 2811 6.1 / PGIII

Synonyms

2-[(3-Chloro-2-methylphenyl)amino](13C6)benzoic acid

MFCD23136996

2-(3-Chloro-2-methylphenylamino)benzoic-13C6 acid

Benzoic-1,2,3,4,5,6-13C6 acid, 2-[(3-chloro-2-methylphenyl)amino]-

Tolfenamic acid-(benzoic ring-13C6)

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