CAS 1432059-16-9|PyrazinaMide-d3
Introduction：Basic information about CAS 1432059-16-9|PyrazinaMide-d3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PyrazinaMide-d3 | ||
|---|---|---|---|
| CAS Number | 1432059-16-9 | Molecular Weight | 126.13 |
| Density | / | Boiling Point | / |
| Molecular Formula | C5H2D3N3O | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | PyrazinaMide-d3 |
|---|
PyrazinaMide-d3 BiologicalActivity
| Description | Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181(7):2044-9. [3]. Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2(4):MGM2-0023-2013. |
Chemical & Physical Properties
| Molecular Formula | C5H2D3N3O |
|---|---|
| Molecular Weight | 126.13 |
