Introduction：Basic information about CAS 146395-14-4|THP-PEG5-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | THP-PEG5-OH |
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| CAS Number | 146395-14-4 | Molecular Weight | 322.395 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 432.5±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H30O7 | Melting Point | / |
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| MSDS | / | Flash Point | 215.4±28.7 °C |
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Names
| Name | THP-PEG6 |
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| Synonym | More Synonyms |
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THP-PEG5-OH BiologicalActivity
| Description | THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 432.5±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H30O7 |
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| Molecular Weight | 322.395 |
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| Flash Point | 215.4±28.7 °C |
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| Exact Mass | 322.199158 |
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| LogP | -1.82 |
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| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
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| Index of Refraction | 1.469 |
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| InChIKey | ZEGHHDSVKRWOCB-UHFFFAOYSA-N |
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| SMILES | OCCOCCOCCOCCOCCOC1CCCCO1 |
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Synonyms
| 3,6,9,12-Tetraoxatetradecan-1-ol, 14-[(tetrahydro-2H-pyran-2-yl)oxy]- |
| 14-(Tetrahydro-2H-pyran-2-yloxy)-3,6,9,12-tetraoxatetradecan-1-ol |
| MFCD26793753 |
