CAS 1977493-48-3|m-PEG12-amine
Introduction：Basic information about CAS 1977493-48-3|m-PEG12-amine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | m-PEG12-amine | ||
|---|---|---|---|
| CAS Number | 1977493-48-3 | Molecular Weight | 559.688 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 583.6±45.0 °C at 760 mmHg |
| Molecular Formula | C25H53NO12 | Melting Point | / |
| MSDS | / | Flash Point | 291.3±22.4 °C |
Names
| Name | MPEG12-NH2 |
|---|---|
| Synonym | More Synonyms |
m-PEG12-amine BiologicalActivity
| Description | m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | PEGs Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References | [1]. Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259. [2]. Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 583.6±45.0 °C at 760 mmHg |
| Molecular Formula | C25H53NO12 |
| Molecular Weight | 559.688 |
| Flash Point | 291.3±22.4 °C |
| Exact Mass | 559.356750 |
| LogP | -4.59 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.458 |
| Storage condition | 2-8°C |
Synonyms
| 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaheptatriacontan-37-amine |
| m-dPEG(R)12-amine |
| MFCD11041151 |
