Introduction：Basic information about CAS 264618-44-2|SSR 146977, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SSR 146977 |
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| CAS Number | 264618-44-2 | Molecular Weight | 621.64 |
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| Density | 1.26 | Boiling Point | / |
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| Molecular Formula | C35H42Cl2N4O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylureahydrochloride |
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SSR 146977 BiologicalActivity
| Description | SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a Ki of 0.26 nM[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor |
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| Target | NK3 |
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| References | [1]. Emonds-Alt X, et, al. Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can J Physiol Pharmacol. 2002 May;80(5):482-8. |
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Chemical & Physical Properties
| Density | 1.26 |
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| Molecular Formula | C35H42Cl2N4O2 |
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| Molecular Weight | 621.64 |
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| InChIKey | XWPBINGFFFZAOZ-UMSFTDKQSA-N |
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| SMILES | CN(C)C(=O)NC1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 |
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| Storage condition | Store at +4°C |
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