Introduction：Basic information about CAS 68562-41-4|Mecasermin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mecasermin |
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| CAS Number | 68562-41-4 | Molecular Weight | / |
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Names
Mecasermin BiologicalActivity
| Description | Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I). Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies[1]. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>IGF-1RResearch Areas >>Metabolic Disease |
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| In Vivo | Mecasermin (rhIGF1; 0.25 mg/kg; i.p.; daily; 6 weeks) 可将血清中的 IGF1 浓度提高至接近正常水平，并改善多种表型，包括机体和行为功能、突触和回路可塑性、神经元结构和分子信号通路[2]。 Animal Model: Mecp2 hemizygous KO mice[2] Dosage: 0.25 mg/kg Administration: i.p.; daily; 6 weeks Result: Improved lifespan, locomotor activity, heart rate, respiration patterns, and social and anxiety behavior. |
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| References | [1]. Arlan L Rosenbloom. Mecasermin (recombinant human insulin-like growth factor I). Adv Ther. 2009 Jan;26(1):40-54. [2]. Jorge Castro, et al. Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9941-6. |
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Chemical & Physical Properties
| No Any Chemical & Physical Properties |
