Introduction：Basic information about CAS 70407-20-4|Territrem B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Territrem B |
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| CAS Number | 70407-20-4 | Molecular Weight | 526.579 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C29H34O9 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | territrem B |
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| Synonym | More Synonyms |
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Territrem B BiologicalActivity
| Description | Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus[1][2]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
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| Target | AChE |
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| In Vitro | Territrem B 与 AChE 活性位点的结合常数 (Ki) 为 1.7 nM[2]。 |
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| References | [1]. Chen JW, et al. Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J Biol Chem. 1999 Dec 3;274(49):34916-23. [2]. Cheung J, et al. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. J Mol Neurosci. 2014 Jul;53(3):506-10. |
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Chemical & Physical Properties
| Molecular Formula | C29H34O9 |
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| Molecular Weight | 526.579 |
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| InChIKey | PBXNNDFKPQPJBB-VJLHXPKFSA-N |
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| SMILES | COc1cc(-c2cc3c(c(=O)o2)CC2(O)C(C)(CCC4(O)C(C)(C)C=CC(=O)C42C)O3)cc(OC)c1OC |
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| Storage condition | 2-8°C |
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Safety Information
Synonyms
