Introduction：Basic information about CAS 870640-62-3|Monomethyl auristatin E intermediate-11, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Monomethyl auristatin E intermediate-11 |
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| CAS Number | 870640-62-3 | Molecular Weight | 221.33852 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C14H23NO | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol |
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Monomethyl auristatin E intermediate-11 BiologicalActivity
| Description | Monomethyl auristatin E intermediate-11 is an intermediate reactant in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| References | [1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. |
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Chemical & Physical Properties
| Molecular Formula | C14H23NO |
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| Molecular Weight | 221.33852 |
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| InChIKey | JPXSDNBZAYWWCL-GXTWGEPZSA-N |
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| SMILES | CCC(C)C(CO)N(C)Cc1ccccc1 |
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