Introduction：Basic information about CAS 1148118-92-6|Tripolin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tripolin A |
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| CAS Number | 1148118-92-6 | Molecular Weight | 253.25274 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C15H11NO3 | Melting Point | 265℃ (decomposition) |
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| MSDS | / | Flash Point | / |
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Names
Tripolin A BiologicalActivity
| Description | Tripolin A ((E)-Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>Aurora KinaseSignaling Pathways >>Cell Cycle/DNA Damage >>Aurora KinaseResearch Areas >>Others |
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| Target | IC50: 1.5 μM (Aurora A), 7 μM (Aurora A)[1]. |
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| In Vitro | Tripolin A induces mitotic spindle defects and spindle pole abnormalities[1]. |
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| References | [1]. Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules. PLoS One. 2013;8(3):e58485. |
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Chemical & Physical Properties
| Melting Point | 265℃ (decomposition) |
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| Molecular Formula | C15H11NO3 |
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| Molecular Weight | 253.25274 |
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| InChIKey | OMKSBDLWMROKNU-WQLSENKSSA-N |
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| SMILES | O=C1Nc2ccccc2C1=Cc1cc(O)ccc1O |
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