Introduction：Basic information about CAS 119189-70-7|Bis-PEG6-acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bis-PEG6-acid |
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| CAS Number | 119189-70-7 | Molecular Weight | 382.403 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 543.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H30O10 | Melting Point | / |
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| MSDS | / | Flash Point | 187.7±23.6 °C |
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Names
| Name | Bis-PEG6-acid |
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| Synonym | More Synonyms |
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Bis-PEG6-acid BiologicalActivity
| Description | Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
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| References | [1]. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 543.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H30O10 |
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| Molecular Weight | 382.403 |
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| Flash Point | 187.7±23.6 °C |
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| Exact Mass | 382.183899 |
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| LogP | -2.26 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.473 |
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| InChIKey | YFBGEYNLLRKUTP-UHFFFAOYSA-N |
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| SMILES | O=C(O)CCOCCOCCOCCOCCOCCOCCC(=O)O |
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Synonyms
| 4,7,10,13,16,19-Hexaoxadocosane-1,22-dioic acid |
| MFCD20926399 |
