Introduction：Basic information about CAS 1456708-45-4|Tos-PEG12-Tos, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tos-PEG12-Tos |
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| CAS Number | 1456708-45-4 | Molecular Weight | 855.019 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 833.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C38H62O17S2 | Melting Point | / |
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| MSDS | / | Flash Point | 457.8±34.3 °C |
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Names
| Name | Tos-PEG13-Tos |
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| Synonym | More Synonyms |
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Tos-PEG12-Tos BiologicalActivity
| Description | Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 833.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C38H62O17S2 |
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| Molecular Weight | 855.019 |
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| Flash Point | 457.8±34.3 °C |
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| Exact Mass | 854.342834 |
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| LogP | -0.88 |
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| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
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| Index of Refraction | 1.507 |
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| InChIKey | BFOYNTMRQQIZSP-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)c2ccc(C)cc2)cc1 |
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Synonyms
| MFCD28334513 |
| 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate) |
| 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diol, bis(4-methylbenzenesulfonate) |
