Introduction：Basic information about CAS 439081-17-1|(R)-Afatinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (R)-Afatinib |
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| CAS Number | 439081-17-1 | Molecular Weight | 485.9384032 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C24H25ClFN5O3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
(R)-Afatinib BiologicalActivity
| Description | (R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib (HY-10261) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFRSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKSignaling Pathways >>Protein Tyrosine Kinase/RTK >>c-Met/HGFR |
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| References | [1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11. |
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Chemical & Physical Properties
| Molecular Formula | C24H25ClFN5O3 |
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| Molecular Weight | 485.9384032 |
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