Introduction：Basic information about CAS 845264-92-8|Atacicept, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Atacicept |
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| CAS Number | 845264-92-8 | Molecular Weight | / |
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Names
Atacicept BiologicalActivity
| Description | Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vivo | Atacicept (TACI-Ig; 100 μg; i.p.; three times of week for 14 days; BALB/c mice) reduces mature B-cell counts and serum antibody levels in normal mice[1]. Atacicept (TACI-Ig) inhibits the progression of disease and autoantibody titers in a mouse model of collagen-induced arthritis (CIA)[1]. Animal Model: Male DBA/1 mice with CIA models[1] Dosage: 100 μg Administration: intraperitoneal injection; three times of week for 21 days Result: Increased serum titers of anti-collagen Abs and few overt signs of disease. Animal Model: BALB/c mice[1] Dosage: 100 μg Administration: intraperitoneal injection; three times of week for 14 days Result: Reduced mature B cell populations but had little effect on other cell lineages. Blocked the development of B cells at the transition from T1 to T2 and the development of MZ B cells in the spleen. Decerased the serum levels of IgM about 2.3-fold. |
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| References | [1]. Gross JA, et, al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity. 2001 Aug;15(2):289-302. [2]. Gross JA, et, al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000 Apr 27;404(6781):995-9. |
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Chemical & Physical Properties
| No Any Chemical & Physical Properties |
