CAS 865363-93-5|MK-8591
Introduction：Basic information about CAS 865363-93-5|MK-8591, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MK-8591 | ||
|---|---|---|---|
| CAS Number | 865363-93-5 | Molecular Weight | 293.2537832 |
| Density | / | Boiling Point | / |
| Molecular Formula | C12H12FN5O3 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 4'-ethynyl-2-fluoro-2'-deoxyadenosine |
|---|---|
| Synonym | More Synonyms |
MK-8591 BiologicalActivity
| Description | MK-8591 is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>HIVSignaling Pathways >>Anti-infection >>Reverse TranscriptaseResearch Areas >>Infection |
| Target | HIV-1 (WT):0.068 nM (EC50) HIV-1 (MDR):0.15 nM (EC50) HIV-1 (M184V):3.1 nM (EC50) |
| In Vitro | MK-8591 (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1]. |
| References | [1]. Ohrui H, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. Chem Rec. 2006;6(3):133-43. |
Chemical & Physical Properties
| Molecular Formula | C12H12FN5O3 |
|---|---|
| Molecular Weight | 293.2537832 |
| InChIKey | IKKXOSBHLYMWAE-QRPMWFLTSA-N |
| SMILES | C#CC1(CO)OC(n2cnc3c(N)nc(F)nc32)CC1O |
Synonyms
| MK-8591 |
