Introduction：Basic information about CAS 99217-64-8|Kushenol B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kushenol B |
|---|
| CAS Number | 99217-64-8 | Molecular Weight | 492.603 |
|---|
| Density | 1.2±0.1 g/cm3 | Boiling Point | 702.3±60.0 °C at 760 mmHg |
|---|
| Molecular Formula | C30H36O6 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 228.2±26.4 °C |
|---|
Names
| Name | Kushenol B |
|---|
| Synonym | More Synonyms |
|---|
Kushenol B BiologicalActivity
| Description | Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities[1]. Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC50 of 31 µM[1]. |
|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>InfectionResearch Areas >>Inflammation/Immunology |
|---|
| Target | IC50: 31 µM (cAMP PDE)[1] |
|---|
| References | [1]. Han-Tian Fan, et al. The rational search for PDE10A inhibitors from Sophora flavescens roots using pharmacophore‑ and docking‑based virtual screening. Mol Med Rep |
|---|
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|
| Boiling Point | 702.3±60.0 °C at 760 mmHg |
|---|
| Molecular Formula | C30H36O6 |
|---|
| Molecular Weight | 492.603 |
|---|
| Flash Point | 228.2±26.4 °C |
|---|
| Exact Mass | 492.251190 |
|---|
| LogP | 8.61 |
|---|
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
|---|
| Index of Refraction | 1.605 |
|---|
| InChIKey | CDNAGJNJVFLMRS-BCHFMIIMSA-N |
|---|
| SMILES | C=C(C)C(CC=C(C)C)Cc1c(O)c(CC=C(C)C)c(O)c2c1OC(c1ccc(O)cc1O)CC2=O |
|---|
Synonyms
| 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)- |
| (2S)-2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-6-(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one |
