Introduction：Basic information about CAS 1228088-30-9|Balovaptan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Balovaptan |
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| CAS Number | 1228088-30-9 | Molecular Weight | 409.912 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 597.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H24ClN5O | Melting Point | / |
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| MSDS | / | Flash Point | 314.9±32.9 °C |
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Names
| Name | balovaptan |
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| Synonym | More Synonyms |
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Balovaptan BiologicalActivity
| Description | Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Vasopressin ReceptorResearch Areas >>Neurological Disease |
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| Target | Ki: 1 nM (hV1a), 39 nM (mV1a)[1] |
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| In Vitro | Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for hV1a and mhV1a, and is used for the research of autism. Balovaptan shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1]. |
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| References | [1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 597.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H24ClN5O |
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| Molecular Weight | 409.912 |
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| Flash Point | 314.9±32.9 °C |
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| Exact Mass | 409.166931 |
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| LogP | 3.16 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.702 |
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Synonyms
| 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-5,6-dihydro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]- |
| RAX5D5AGV6 |
| 8-Chloro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine |
| 10298 |
| balovaptan |
