Introduction：Basic information about (1R,2R)-(-)-1,2-Diaminocyclohexane CAS 20439-47-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(1R,2R)-(-)-1,2-Diaminocyclohexane Basic information
| Product Name: | (1R,2R)-(-)-1,2-Diaminocyclohexane |
| Synonyms: | RR-DIAMINOCYCLOHEXANE;RR-DAC;(-)-(R,R)-DACH;(R,R)-DACH;(-)-(R,R)-1,2-DIAMINOCYCLOHEXANE;(1R,2R)-(-)-1,2-CYCLOHEXANEDIAMINE;(1R,2R)-CYCLOHEXANE-1,2-DIAMINE;(1R,2R)-(-)-1,2-DIAMINOCYCLOHEXANE |
| CAS: | 20439-47-8 |
| MF: | C6H14N2 |
| MW: | 114.19 |
| EINECS: | 606-556-6 |
| Product Categories: | organic amine;Amines;Miscellaneous Reagents;Chiral Nitrogen;DACH&Trost Series;API intermediates;Chiral reagent;chiral;Amines (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;CHIRAL CHEMICALS;Chiral Compound;Cycloalkanes |
| Mol File: | 20439-47-8.mol |
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(1R,2R)-(-)-1,2-Diaminocyclohexane Chemical Properties
| Melting point | 41-45 °C |
| alpha | -24.5 º (c=5 1 N HCl 20 º 26.5 ºC) |
| Boiling point | 86-88°C 23mm |
| density | 0.931 |
| refractive index | -25.5 ° (C=5, 1mol/L HCl) |
| Fp | 169 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Aqueous Acid (Slightly), Chloroform (Sparingly), Methanol (Slightly) |
| pka | 10.76±0.70(Predicted) |
| form | Crystalline Low Melting Solid |
| color | White to pale yellow |
| Optical Rotation | [α]20/D 25°, c = 5 in 1 M HCl |
| Water Solubility | Soluble in water. |
| Sensitive | Air Sensitive |
| BRN | 4780911 |
| Stability: | Air Sensitive |
| InChI | 1S/C6H14N2/c7-5-3-1-2-4-6(5)8/h5-6H,1-4,7-8H2/t5-,6-/m1/s1 |
| InChIKey | SSJXIUAHEKJCMH-PHDIDXHHSA-N |
| SMILES | N[C@@H]1CCCC[C@H]1N |
| CAS DataBase Reference | 20439-47-8(CAS DataBase Reference) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3259 8/PG 2 |
| WGK Germany | 3 |
| F | 10-34 |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29213000 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1B |
(1R,2R)-(-)-1,2-Diaminocyclohexane Usage And Synthesis
| Chemical Properties | white to light yellow crystal powder |
| Uses | (1R,2R)-(-)-1,2-Diaminocyclohexane can be used as a building block for chiral ligands. |
| Uses | suzuki reaction |
| Uses | (1R,2R)-(-)-1,2-Diaminocyclohexane is a versatile ligand for the formation of metal complexes. Used in the synthesis of chiral tropocoronands which have potential utility in asymmetric catalysis. |
| Purification Methods | Distil or recrystallise the diamine from pet ether under N2 or Ar. Store it as above. The 1R,2R-base L-tartrate salt has M 264.3, m 2 7 3o and [ ] D +12.5o (c 4, H2O), and can be used to purfy and/or optically enrich the free base. [Beilstein 13 III 6, and references below.] |
(1R,2R)-(-)-1,2-Diaminocyclohexane Preparation Products And Raw materials
| Raw materials | Acetic acid-->Potassium hydroxide-->tert-Butyl methyl ether-->L(+)-Tartaric acid-->D-(-)-Tartaric Acid-->3-Methylbenzoyl chloride-->(+/-)-trans-1,2-Diaminocyclohexane-->2-Aminocyclohexanol-->cis-1,2-Diaminocyclohexane-->1,2-Diaminocyclohexane-->(1S,2S)-(+)-1,2-Diaminocyclohexane |
| Preparation Products | (1R,2R)-(+)-1,2-DIAMINOCYCLOHEXANE-N,N'-BIS(2-DIPHENYLPHOSPHINO-1-NAPHTHOYL)-->Acetamide, N,N'-(1R,2R)-1,2-cyclohexanediylbis[2-chloro--->Phenol, 2,2'-[(1R,2R)-1,2-cyclohexanediylbis(nitrilomethylidyne)]bis[4,6-bis(1,1-dimethylethyl)--->2(1H)-Quinoxalinone,octahydro-,(4aR-trans)-(9CI)-->Phenol, 2,2'-[(1R,2R)-1,2-cyclohexanediylbis(nitrilomethylidyne)]bis[4-bromo--->1-(pyridin-2-yl)-N-[(1R,2R)-2-{[(pyridin-2-yl)methylidene]amino}cyclohexyl]methanimine |
