(1S,2S)-(+)-Pseudoephedrine hydrochloride CAS 345-78-8
Introduction：Basic information about (1S,2S)-(+)-Pseudoephedrine hydrochloride CAS 345-78-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(1S,2S)-(+)-Pseudoephedrine hydrochloride Basic information
| Product Name: | (1S,2S)-(+)-Pseudoephedrine hydrochloride |
| Synonyms: | (+)-PSI-EPHEDRINE HYDROCHLORIDE;PSI-EPHEDRINE HYDROCHLORIDE;PSEUDOEPHEDRINE HCL;PSEUDOEPHEDRINE HCL, (+)-1S,2S-;PSEUDOEPHEDRINE HYDROCHLORIDE;a)]-;alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r*,r*))-benzenemethano;benzenemethanol,alpha-[1-(methylamino)ethyl]-,hydrochloride,[s-(theta,thet |
| CAS: | 345-78-8 |
| MF: | C10H16ClNO |
| MW: | 201.69 |
| EINECS: | 206-462-1 |
| Product Categories: | Pharmaceutical Raw Materials;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;API's |
| Mol File: | 345-78-8.mol |
(1S,2S)-(+)-Pseudoephedrine hydrochloride Chemical Properties
| Melting point | 185-188 °C(lit.) |
| alpha | 61 º (c=5, H2O,2dm tube) |
| storage temp. | Refrigerator (+4°C) |
| solubility | Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride. |
| pka | 9.22(at 25℃) |
| form | buffered aqueous solution |
| biological source | rabbit |
| Merck | 13,8007 |
| BRN | 3915112 |
| LogP | -1.74 at 23℃ and pH7 |
| CAS DataBase Reference | 345-78-8(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (345-78-8) |
Safety Information
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-36/37/38-36/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-24/25-45-36/37-16-7 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | UL5950000 |
| TSCA | TSCA listed |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29394200 |
| Storage Class | 10 - Combustible liquids |
| Toxicity | LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles) |
| Chemical Properties | white powder |
| Uses | Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor. |
| Definition | ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine. |
| Brand name | Efidac (ALZA); Novafed (Sanofi Aventis);Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert). |
| Biological Activity | Trefoil factor 1 is a protein encoded by the TFF1 gene in humans. The proteins are small secretory proteins characterized by three intra-chain disulfide bonds forming the trefoil motif or P-domain. It is abundantly expressed on mucosal surfaces and especially within the gastrointestinal tract. The protein belongs to highly conserved proteins th at play an essential role in epithelial regeneration within the gastrointestinal tract. Its expression is strongly induced after mucosal injury and may function as a gastric tumor suppressor gene. It is expressed in various types of carcinomas including breast cancer. The gene contains an estrogen response element and its expression can be regulated by estrogen. Increased expression of this gene is found to be associated with tumor progression in some tumors and missense mutations in the gene have been detected in gastric cancer. |
| Contact allergens | This sympathomimetic a-adrenergic agonist is foundin plants of the genus Ephedra (Ephedraceae) and issystemically used as a nasal decongestant. It can inducedrug skin reactions such as acute generalized exanthematicpustulosis or generalized eczema. |
| Clinical Use | Nasal decongestant |
| Drug interactions | Potentially hazardous interactions with other drugs Adrenergic neurone blockers: antagonise hypotensive effect of adrenergic neurone blockers. Anaesthetics: increased risk of ventricular arrhythmias with isoflurane. Antibacterials: risk of hypertensive crisis with linezolid. Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide. Dopaminergics: avoid concomitant use with selegiline and rasagiline. |
| Metabolism | A small amount of pseudoephedrine is hepatically metabolised by N-demethylation. It is excreted largely unchanged in the urine with small amounts of its hepatic metabolite. |
| Purification Methods | 1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.] |
(1S,2S)-(+)-Pseudoephedrine hydrochloride Preparation Products And Raw materials
