Introduction：Basic information about (FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE CAS 2136-75-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Basic information
| Product Name: | (FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE |
| Synonyms: | (Formylmethylene)triphenylphosphorane, 97%, may cont. up to ca 3% water;FORMYLMETHYLENETRIPHENYLPHOSPORANE;Formylmethylenetriphenylphosphorane, 98 %;2-(Triphenylphosphoranylidene)acetaldehyde;2-Oxoethylidenetriphenylphosphorane;Triphenyl(2-oxoethylidene)phosphorane;(Triphenylphosphoranylidene)acetaldehyde,97%;(Triphenylphosphoranylidene)acetaldehydeDISC 10/19/00 |
| CAS: | 2136-75-6 |
| MF: | C20H17OP |
| MW: | 304.32 |
| EINECS: | 218-375-6 |
| Product Categories: | Wittig Reagents;Synthetic Organic Chemistry;Wittig & Horner-Emmons Reaction;Wittig Reaction |
| Mol File: | 2136-75-6.mol |
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(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Chemical Properties
| Melting point | 185-188 °C(lit.) |
| Boiling point | 472.6±28.0 °C(Predicted) |
| density | 1.16±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in Chloroform, Methanol. |
| form | Fine Crystalline Powder |
| color | Pink to brown |
| Sensitive | Air Sensitive |
| BRN | 523797 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C20H17OP/c21-16-17-22(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-17H |
| InChIKey | CQCAYWAIRTVXIY-UHFFFAOYSA-N |
| SMILES | C(=O)C=P(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1 |
| CAS DataBase Reference | 2136-75-6(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Hazard Note | Irritant/Keep Cold/Air Sensitive |
| HS Code | 29319090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Usage And Synthesis
| Chemical Properties | pink to brown crystalline powder |
| Uses | (Formylmethylene)triphenylphosphorane is used as Wittig reagent. It is also used as Pharmaceutical Intermediates. It is employed as raw material in organic Synthesis, Agrochemicals. |
| Uses | Wittig reagent for the conversion of aldehydes and ketones to two-carbon homologated, α,β-unsaturated carbonyl compounds. |
| reaction suitability | reaction type: C-C Bond Formation |
| Purification Methods | Recrystallise it from Me2CO, or dissolve it in *C6H6, wash with N NaOH, dry (MgSO4), evaporate, and crystallise the residue from Me2CO. It can be prepared from its precursor, formylmethyltriphenylphosphonium chloride (which crystallises from CHCl3/EtOAc), by treatment with Et3N and extraction with *C6H6. [Tripett & Walker J Chem Soc 1266 1961.] |
(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Preparation Products And Raw materials
| Preparation Products | (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one-->Diphenylacetylene-->VINYLCYCLOHEXANE-->3,5-BIS(BENZYLOXY)BENZYL BROMIDE-->3-NAPHTHALEN-2-YL-PROPIONALDEHYDE-->Cefdinir-->3-（trifluoromethyl) Cinnamaldehyde-->5-Nitrofuran-2-acrylaldehyde-->FENPICLONIL-->2-Propenal, 3-(2-thiazolyl)-, (2E)--->2-Propenal, 3-(3,5-difluorophenyl)-, (2E)--->(2E,2'E)-3,3'-(1,4-phenylene)diacrylaldehyde |
