Introduction：Basic information about (R)-(-)-alpha-Methoxyphenylacetic acid CAS 3966-32-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(R)-(-)-alpha-Methoxyphenylacetic acid Basic information
| Product Name: | (R)-(-)-alpha-Methoxyphenylacetic acid |
| Synonyms: | (R)-(-)-METHOXYPHENYLACETIC ACID;O-METHYL-D-MANDELIC ACID;(R)-(-)-ALPHA-METHOXYPHENYLACETIC ACID;(R)-ALPHA-METHOXYPHENYLACETIC ACID;(R)-(-)-A-METHOXYPHENYLACETIC ACID;Benzeneacetic acid, alpha-methoxy-, (R)-;Acetic acid, methoxyphenyl- (8CI);Benzeneacetic acid, .a |
| CAS: | 3966-32-3 |
| MF: | C9H10O3 |
| MW: | 166.17 |
| EINECS: | 223-580-9 |
| Product Categories: | Analytical Chemistry;Carboxylic Acids (Chiral);Chiral Building Blocks;e.e. / Absolute Configuration Determination (NMR);Enantiomer Excess & Absolute Configuration Determination;Synthetic Organic Chemistry |
| Mol File: | 3966-32-3.mol |
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(R)-(-)-alpha-Methoxyphenylacetic acid Chemical Properties
| Melting point | 66-68 °C(lit.) |
| alpha | -160.4 º (C=1, MEOH) |
| Boiling point | 164-166°C 18mm |
| density | 1.1708 (rough estimate) |
| refractive index | -147 ° (C=0.5, EtOH) |
| Fp | 164-166°C/18mm |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethanol, Methanol |
| pka | 3.10±0.10(Predicted) |
| form | Fine Crystalline Powder or Needles |
| color | White |
| Optical Rotation | [α]20/D -150±3°, c = 0.5% in ethanol |
| BRN | 3589257 |
| InChI | 1S/C9H10O3/c1-12-8(9(10)11)7-5-3-2-4-6-7/h2-6,8H,1H3,(H,10,11)/t8-/m1/s1 |
| InChIKey | DIWVBIXQCNRCFE-MRVPVSSYSA-N |
| SMILES | CO[C@@H](C(O)=O)c1ccccc1 |
| CAS DataBase Reference | 3966-32-3(CAS DataBase Reference) |
| NIST Chemistry Reference | (R)-(-)-«alpha»-methoxyphenylacetic acid(3966-32-3) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 29189900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
(R)-(-)-alpha-Methoxyphenylacetic acid Usage And Synthesis
| Chemical Properties | white fine crystalline powder or needles |
| Uses | (R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors. |
| General Description | (R)-(?)-α-Methoxyphenylacetic acid is a chiral derivatizating agent, which is employed for derivatizing enantiomers into diastereoisomers. |
| Purification Methods | Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.] |
(R)-(-)-alpha-Methoxyphenylacetic acid Preparation Products And Raw materials
| Raw materials | DL-alpha-Methoxyphenylacetic acid |
