(R)-(+)-Glycidol CAS 57044-25-4

Introduction：Basic information about (R)-(+)-Glycidol CAS 57044-25-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(R)-(+)-Glycidol Basic information

• Product Name: (R)-(+)-Glycidol
• Synonyms: EOS-60676;(r)-oxiranemethano;(R)-(+)-2,3-EPOXY-1-PROPANOL;(R)-(+)-GLYCIDOL;(R)-GLYCIDOL;R(+)-OXIRANE-2-METHANOL;(R)-Oxiranemethanol;OXIRANEMETHANOL, (2R)-
• CAS: 57044-25-4
• MF: C3H6O2
• MW: 74.08
• EINECS: 404-660-4
• Product Categories: Chiral Compound;CHIRAL COMPOUNDS;chiral;API intermediates
• Mol File: 57044-25-4.mol

(R)-(+)-Glycidol Chemical Properties

• Boiling point: 56-57 °C11 mm Hg(lit.)
• density: 1.116 g/mL at 20 °C(lit.)
• refractive index: n20/D 1.43(lit.)
• Fp: 178 °F
• storage temp.: -20°C
• Water Solubility: Completely miscible in water
• solubility: Chloroform (Slightly), DMSO (Slightly)
• pka: 14.62±0.10(Predicted)
• color: Colorless to Light yellow
• Optical Rotation: [α]23/D +15°, neat
• BRN: 79782
• Stability: Moisture Sensitive
• InChI: 1S/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2/t3-/m1/s1
• InChIKey: CTKINSOISVBQLD-GSVOUGTGSA-N
• SMILES: OC[C@@H]1CO1
• CAS DataBase Reference: 57044-25-4(CAS DataBase Reference)
• NIST Chemistry Reference: Oxiranemethanol, (R)-(57044-25-4)

Safety Information

• Hazard Codes: T,E
• Risk Statements: 45-60-2-21/22-23-34-68-41-37/38
• Safety Statements: 53-45-36/37/39-26
• RIDADR: UN 2922 8/PG 2
• WGK Germany: 3
• RTECS: RR0508000
• F: 10-21
• HazardClass: 6.1
• PackingGroup: Ⅲ
• HS Code: 29109000
• Storage Class: 5.2 - Organic peroxides and self-reacting hazardous materials
• Hazard Classifications: Acute Tox. 2 Inhalation Acute Tox. 4 Dermal Acute Tox. 4 Oral Carc. 1B Eye Dam. 1 Muta. 2 Repr. 1B Self-react. C Skin Corr. 1B STOT SE 3

(R)-(+)-Glycidol Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(+)-Glycidol may be used in the following synthesis:

• heteroarylpropane-2,3-diols, useful for combinatorial oligomer synthesis
• enantiomerically pure (2S,3S)- and (2S,3R)-threoninol and -hydroxyphenylalaninol
• 2-amino-1,4-anhydro-pentitol and 3-amino-1,5-anhydro-4-deoxy-hexitol with the arabino configuration
• (S)-4-tosyloxymethyl-2-oxazolidinone, required for the synthesis of protected amino alcohol derivatives
• 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine [(S)-HPMPC]
• chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product

Uses

(R)-(+)-Glycidol can be used to construct chiral building blocks of epoxyvinyl iodide intermediates in the synthesis of furanocembrane, a marine natural product.

Definition

ChEBI: (R)-glycidol is a glycidol. It is functionally related to a (R)-1,2-epoxypropane. It is an enantiomer of a (S)-glycidol.

General Description

Enantioselective esterification of (R)-(+)-glycidol with n-butyric acid in organic media using hybrid gel-entrapped lipase on Celite has been reported.

Purification Methods

[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.

(R)-(+)-Glycidol Preparation Products And Raw materials

• Preparation Products: (S)-(+)-Methyl glycidyl ether-->(S)-(+)-Glycidyl butyrate-->1,2-Propanediol, 3-(dodecyloxy)-, (2R)--->(S)-2-((2-FLUOROPHENOXY)METHYL)OXIRANE