(R)-3-Aminopyrrolidine CAS 116183-82-5
(R)-3-Aminopyrrolidine Basic information
| Product Name: | (R)-3-Aminopyrrolidine |
| Synonyms: | (3R)-Pyrrolidine-3-amine;(3R)-pyrrolidin-3-aMine;(R)-(+)-3-Aminopyrrolidine 98%;3-amino-R-pyrrolidine;(3R)-3-Pyrrolidinamine;(3R)-(+)-3-AMINOPYRROLIDINE 98+%;(R)-pyrrolidin-3-amine;(r)-(R)-3-AMinopyrrolidine |
| CAS: | 116183-82-5 |
| MF: | C4H10N2 |
| MW: | 86.14 |
| EINECS: | |
| Product Categories: | Chiral Building Blocks;Heterocyclic Building Blocks;3-Aminopyrrolidines;Amines (Chiral);Chiral 3-Aminopyrrolidines;Pyrrolidines;pharmacetical;Pyrrole&Pyrrolidine&Pyrroline;API intermediates;Chiral Building Blocks;Synthetic Organic Chemistry;Chiral Compound |
| Mol File: | 116183-82-5.mol |
(R)-3-Aminopyrrolidine Chemical Properties
| Boiling point | 164-165 °C(lit.) |
| density | 0.984 g/mL at 25 °C(lit.) |
| refractive index | n |
| Fp | 147 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 9.94±0.20(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Optical Rotation | [α]/D +20°, neat |
| InChI | 1S/C4H10N2/c5-4-1-2-6-3-4/h4,6H,1-3,5H2/t4-/m1/s1 |
| InChIKey | NGXSWUFDCSEIOO-SCSAIBSYSA-N |
| SMILES | N[C@@H]1CCNC1 |
| CAS DataBase Reference | 116183-82-5(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | 3 |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29339900 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
| Synthesis | 114715-38-7 79286-79-6 General procedure for the synthesis of (S)-3-aminopyrrolidine from (S)-1-benzyl-3-aminopyrrolidine: 7.0 g of (S)-1-benzyl-3-aminopyrrolidine, 25 mL of methanol, and 0.7 g of 5% Pd/C catalyst were added to a 100 mL autoclave. The hydrogen pressure was adjusted to 1 MPa, the temperature was raised to 70 °C and the reaction was kept stirring for 8 hours. Upon completion of the reaction, it was cooled to room temperature and the pressure was slowly released. The reaction mixture was filtered to remove the catalyst and the mother liquor was concentrated and purified by distillation to collect the 80-83 °C/40 kPa fraction to give 3.2 g of (S)-3-aminopyrrolidine. The product was analyzed with 99% chemical purity and 90% optical purity e.e. |
| References | [1] Patent: US6348600, 2002, B1. Location in patent: Page column 14 [2] Patent: EP1640364, 2006, A1. Location in patent: Page/Page column 10 [3] Patent: EP1236716, 2002, A1. Location in patent: Example 6 |
(R)-3-Aminopyrrolidine Preparation Products And Raw materials
| Raw materials | (S)-(+)-1-Benzyl-3-aminopyrrolidine-->(S)-3-(Boc-amino)pyrrolidine-->Methanol-->Hydrogen |
| Preparation Products | (R)-3-(Boc-amino)pyrrolidine |
