(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone CAS 77877-19-1

Introduction：Basic information about (S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone CAS 77877-19-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone Basic information

• Product Name: (S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone
• Synonyms: (S)-3-Propionyl-4-isopropyl-2-oxazolidinone,99%e.e.;(S)-(+)-4-ISOPROPYL-3-PROPIONYL-2-OXAZOLIDINONE;(S)-4-ISOPROPYL-3-PROPIONYL-2-OXAZOLIDINONE;(S)-3-PROPIONYL-4-ISOPROPYL-2-OXAZOLIDINONE;N-PROPIONYL-(4S)-ISOPROPYL- 2-OXAZOLIDINONE;(S)-(+)-4-isopropyl-3-propimyl-2-oxazolidimone;(S)-(+)-4-ISOPRPYL-3-PROPIONYL-2-OXAZOLIDINONE;(S)-(+)-4-Isoprpyl-3-Propion
• CAS: 77877-19-1
• MF: C9H15NO3
• MW: 185.22
• Product Categories: Oxazolidinone;chiral;Asymmetric Synthesis;Chiral Building Blocks;Glycidyl Compounds, etc. (Chiral);Synthetic Organic Chemistry;Peptide
• Mol File: 77877-19-1.mol

(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone Chemical Properties

• alpha: 93 º (c=8.7 in methylene chloride)
• Boiling point: 102-106 °C0.75 mm Hg(lit.)
• density: 1.094 g/mL at 25 °C(lit.)
• refractive index: n20/D 1.465
• Fp: >230 °F
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• form: clear liquid
• color: Colorless to Almost colorless
• Optical Rotation: [α]25/D +93°, c = 8.7 in methylene chloride
• BRN: 3542849
• InChI: 1S/C9H15NO3/c1-4-8(11)10-7(6(2)3)5-13-9(10)12/h6-7H,4-5H2,1-3H3/t7-/m1/s1
• InChIKey: HOWPHXVPNNPSAZ-SSDOTTSWSA-N
• SMILES: CCC(=O)N1[C@H](COC1=O)C(C)C
• CAS DataBase Reference: 77877-19-1(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 23-24/25-36-26
• WGK Germany: 3
• F: 3-10
• HS Code: 29349990
• Storage Class: 10 - Combustible liquids

(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone is used as a reactant in the preparation of oxazolidinone derivatives as IL-6 signaling blockers.

References

[1] Patent: WO2008/127070, 2008, A1. Location in patent: Page/Page column 13-14
[2] Organic Letters, 2013, vol. 15, # 3, p. 472 - 475

(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone Preparation Products And Raw materials

• Raw materials: (4S)-(-)-4-Isopropyl-2-oxazolidinone-->CBZ-L-VALINOL-->(S)-(+)-2-Amino-3-methyl-1-butanol-->1-PROPIONYLIMIDAZOLE-->(R)-(+)-4-Isopropyl-2-oxazolidinone-->Lithium chloride-->Propionic-2,3-14C1 acid (8CI)-->L-Valine-->Propionic anhydride-->Propionyl chloride