(S)-(+)-alpha-Methoxyphenylacetic acid CAS 26164-26-1

Introduction：Basic information about (S)-(+)-alpha-Methoxyphenylacetic acid CAS 26164-26-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(S)-(+)-alpha-Methoxyphenylacetic acid Basic information

• Product Name: (S)-(+)-alpha-Methoxyphenylacetic acid
• Synonyms: (S)-(+)-METHOXYPHENYLACETIC ACID;(S)-(+)-A-METHOXYPHENYLACETIC ACID;(S)-(+)-ALPHA-METHOXYPHENYLACETIC ACID;(S)-ALPHA-METHOXYPHENYLACETIC ACID;(S)-(+)-A-METHOXYPHENYLACETIC ACID FLU&;O-Methyl-(S)-mandelicacid;(s)-(+)-à-methoxyphenylacetic acid;(S)-(+)-α-Methoxyphenylacetic acid, 99%, for chiral derivatization
• CAS: 26164-26-1
• MF: C9H10O3
• MW: 166.17
• EINECS: 247-492-5
• Product Categories: Analytical Chemistry;Carboxylic Acids (Chiral);Chiral Building Blocks;e.e. / Absolute Configuration Determination (NMR);Enantiomer Excess & Absolute Configuration Determination;Synthetic Organic Chemistry;Chiral Reagents
• Mol File: 26164-26-1.mol

(S)-(+)-alpha-Methoxyphenylacetic acid Chemical Properties

• Melting point: 64-66 °C(lit.)
• alpha: 160 º (C=1, MEOH)
• Boiling point: 164-166°C 18mm
• density: 1.1708 (rough estimate)
• refractive index: 147 ° (C=0.5, EtOH)
• Fp: 164-166°C/18mm
• storage temp.: Sealed in dry,Room Temperature
• solubility: Chloroform (Slightly), Ethanol (Slightly)
• pka: 3.10±0.10(Predicted)
• form: Fine Crystalline Powder or Crystals
• color: White
• Optical Rotation: [α]17/D +150°, c = 1 in ethanol
• Water Solubility: Soluble
• BRN: 2361718
• InChI: 1S/C9H10O3/c1-12-8(9(10)11)7-5-3-2-4-6-7/h2-6,8H,1H3,(H,10,11)/t8-/m0/s1
• InChIKey: DIWVBIXQCNRCFE-QMMMGPOBSA-N
• SMILES: CO[C@H](C(O)=O)c1ccccc1
• CAS DataBase Reference: 26164-26-1(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, «alpha»-methoxy-, (s)-(26164-26-1)

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HS Code: 29189900
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

(S)-(+)-alpha-Methoxyphenylacetic acid Usage And Synthesis

Chemical Properties

White Solid

Uses

(S)-(+)-α-Methoxyphenylacetic Acid (cas# 26164-26-1) is a compound useful in organic synthesis.

Uses

Reactant involved in the synthesis of biologically active molecules including:

• Acyclonucleoside phosphonates structural analogs of adefovir
• Labeled discodermolide for studying binding to tubulin
• 10-Isocyano-4-cadinene used for antifouling activity

Reactant involved in studies of immunostimulating chromanones gonytolides A-C

Reactant involved in:

• Hydroxylations and epoxidations
• Hydrogenations

Purification Methods

Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.]

(S)-(+)-alpha-Methoxyphenylacetic acid Preparation Products And Raw materials

• Raw materials: Ethanol-->Methanol-->Sulfuric acid-->Thionyl chloride-->PETROLEUM ETHER-->Chloroform-->Magnesium sulfate-->Sodium chloride-->Iodomethane-->Silver oxide-->CALCIUM SULFATE-->(S)-(+)-Mandelic acid