(S)-(+)-Methyl mandelate CAS 21210-43-5
(S)-(+)-Methyl mandelate Basic information
| Product Name: | (S)-(+)-Methyl mandelate |
| Synonyms: | METHYL (S)-(+)-MANDELATE;(+)-METHYL (S)-ALPHA-HYDROXY-PHENYL ACETATE;METHYL (S)-ALPHA-HYDROXYPHENYLACETATE;(+)-METHYL L-MANDELATE;METHYL L-(+)-MANDELATE;(+)-L-MANDELIC ACID METHYL ESTER;L-(+)-MANDELIC ACID METHYL ESTER;S-Plus-mandelic acid methyl |
| CAS: | 21210-43-5 |
| MF: | C9H10O3 |
| MW: | 166.17 |
| EINECS: | 145-896-5 |
| Product Categories: | Aromatics;Chiral Reagents;Chiral Building Blocks;Esters (Chiral);Synthetic Organic Chemistry;Chiral Compound |
| Mol File: | 21210-43-5.mol |
(S)-(+)-Methyl mandelate Chemical Properties
| Melting point | 56-58 °C |
| alpha | 142 º (c=2, MeOH) |
| Boiling point | 138 °C / 16mmHg |
| density | 1.1097 (rough estimate) |
| refractive index | 1.4371 (estimate) |
| Fp | >110°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Sparingly), Methanol (Sparingly) |
| pka | 12.19±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| Optical Rotation | [α]20/D +144°, c = 1 in methanol |
| BRN | 2614741 |
| InChI | 1S/C9H10O3/c1-12-9(11)8(10)7-5-3-2-4-6-7/h2-6,8,10H,1H3/t8-/m0/s1 |
| InChIKey | ITATYELQCJRCCK-QMMMGPOBSA-N |
| SMILES | COC(=O)[C@@H](O)c1ccccc1 |
| CAS DataBase Reference | 21210-43-5(CAS DataBase Reference) |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29181990 |
| Storage Class | 11 - Combustible Solids |
| Chemical Properties | white crystalline powder |
| Uses | Methyl (S)-(+)-Mandelate (cas# 21210-43-5) is a compound useful in organic synthesis. |
| Uses | Methyl (S)-(+)-mandelate may be used in the preparation of (S)-(-)2-hydroxy-1,2,2-triphenylethyl acetate and (α′S)-α′-methoxycarbonylbenzyl (2S,4R)-(+)-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxylate. |
| General Description | Optically active building block. |
| Synthesis | 67-56-1 17199-29-0 21210-43-5 GENERAL METHOD: To a stirred solution of 0.1 mol α-acetoxymandelic acid or α-hydroxymandelic acid dissolved in 200 mL of anhydrous methanol at -30°C was slowly added 8.1 mL (13.05 g, 0.11 mol) of thionyl chloride. The reaction solution was continued to be stirred at -30°C for 15 minutes and then moved to room temperature for 48 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was adjusted to pH 9 with NaHCO3 solution and subsequently extracted with ether (5 x 50 mL) and the organic phase was dried with MgSO4. After evaporation of the solvent, the resulting (S)-2-hydroxy-2-phenylacetic acid methyl ester crude was purified by either reduced pressure distillation or petroleum ether-toluene mixed solvent crystallization. |
| References | [1] Patent: JP2005/120020, 2005, A. Location in patent: Page/Page column 9 [2] Angewandte Chemie, International Edition, 2009, vol. 48, # 25, p. 4605 - 4609 [3] Angewandte Chemie, International Edition, 2014, vol. 53, # 37, p. 9860 - 9864,5 [4] Angewandte Chemie, 2014, vol. 126, # 37, p. 10018 - 10022,5 [5] Chemistry Letters, 1997, # 1, p. 55 - 56 |
(S)-(+)-Methyl mandelate Preparation Products And Raw materials
| Raw materials | Methanol-->Thionyl chloride-->Chloroform-->Magnesium sulfate-->Sodium chloride-->(S)-(+)-Mandelic acid-->Methyl benzoylformate |
| Preparation Products | (R)-(-)-ALPHA-(TRIFLUOROMETHYL)BENZYL ALCOHOL-->(S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE |
