(S)-5-AMINO-PIPERIDIN-2-ONE HCL CAS 672883-95-3

Introduction：Basic information about (S)-5-AMINO-PIPERIDIN-2-ONE HCL CAS 672883-95-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(S)-5-AMINO-PIPERIDIN-2-ONE HCL Basic information

• Product Name: (S)-5-AMINO-PIPERIDIN-2-ONE HCL
• Synonyms: 4-(S)-AMINO-D-VALEROLACTAM HCL;(S)-5-AMINO-PIPERIDIN-2-ONE HCL;(S)-5-AMINOPIPERIDIN-2-ONE HYDROCHLORIDE;2-Piperidinone, 5-amino-, monohydrochloride, (5S)-;(S)-5-AMINO-PIPERIDIN-2-ONEHCL (MFCD03094719);(S)-4-Amino-delta-valerolactam hydrochloride;(5S)-5-Aminopiperidin-2-one . x hydrochloride;(5S)-5-aminopiperidin-2-one hydrochloride
• CAS: 672883-95-3
• MF: C5H11ClN2O
• MW: 150.61
• Product Categories: pharmacetical
• Mol File: 672883-95-3.mol

(S)-5-AMINO-PIPERIDIN-2-ONE HCL Chemical Properties

• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• form: solid
• color: White

Safety Information

• Hazard Codes: Xn
• Risk Statements: 22
• HS Code: 2933399990

(S)-5-AMINO-PIPERIDIN-2-ONE HCL Usage And Synthesis

Application

(S)-5-amino-piperidin-2-one hydrochloride is an organic intermediate that can be prepared from L-glutamic acid-5-methyl ester through a six-step reaction.

Synthesis

Starting with L-glutamic acid-5-methyl ester, it was first reacted with di-tert-butyl dicarbonate in a triethylamine/DMF system at 50°C for 1 hour, then incubated overnight at room temperature. Column chromatography yielded a Boc-protected intermediate. This intermediate was dissolved in THF, reduced at -10°C with N-methylmorpholine, ethyl chloroformate, and sodium borohydride, quenched with saturated ammonium chloride, and purified by extraction to obtain a hydroxyl intermediate. This hydroxyl intermediate was then reacted with p-toluenesulfonyl chloride and triethylamine in dichloromethane at room temperature, and column chromatography yielded a sulfonyloxy intermediate. Subsequently, it was heated with sodium azide in DMF at 50°C for 3 hours to purify an azide intermediate. The azide intermediate was dissolved in methanol and hydrogenated overnight under atmospheric pressure using a 10% palladium/carbon catalyst. The solvent was removed by filtration to obtain a cyclization product. Finally, the cyclization product was dissolved in ethanol, and acetyl chloride was added at 0°C. The mixture was stirred at room temperature for 1 hour, and the solvent was removed under reduced pressure to obtain (S)-5-amino-piperidin-2-one hcl.