Introduction：Basic information about 1-(2-Hydroxyethyl)piperazine CAS 103-76-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1-(2-Hydroxyethyl)piperazine Basic information
| Product Name: | 1-(2-Hydroxyethyl)piperazine |
| Synonyms: | 2-(Piperazin-1-yl)ethan-1-ol, 1-Hydroxy-2-(piperazin-1-yl)ethane;NSC 26884;NSC 38969;NSC 60706;HydroxyethylPiperazine /1-Piperazineethanol;1-Piperazineethanol ,98%;1-(2-Hydroxyethyl)piperazine,2-Piperazinoethanol, Piperazine-1-ethanol;N-(2-Hydroxyethyl)pi |
| CAS: | 103-76-4 |
| MF: | C6H14N2O |
| MW: | 130.19 |
| EINECS: | 203-142-3 |
| Product Categories: | Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks;Piperazines;Piperaizine;103-76-4 |
| Mol File: | 103-76-4.mol |
|
1-(2-Hydroxyethyl)piperazine Chemical Properties
| Melting point | -38.5 °C |
| Boiling point | 246 °C(lit.) |
| density | 1.061 g/mL at 25 °C(lit.) |
| vapor pressure | 0.007 hPa (20 °C) |
| refractive index | n20/D 1.506(lit.) |
| Fp | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 14.96±0.10(Predicted) |
| form | Oily Liquid |
| color | Clear colorless to pale yellow |
| Specific Gravity | 1.060 |
| PH | 12.3 (100g/l, H2O, 20℃) |
| explosive limit | 1.4-8.9%(V) |
| Water Solubility | MISCIBLE |
| BRN | 104361 |
| InChI | 1S/C6H14N2O/c9-6-5-8-3-1-7-2-4-8/h7,9H,1-6H2 |
| InChIKey | WFCSWCVEJLETKA-UHFFFAOYSA-N |
| SMILES | OCCN1CCNCC1 |
| LogP | -1.47 at 25℃ |
| CAS DataBase Reference | 103-76-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Piperazineethanol(103-76-4) |
| EPA Substance Registry System | 1-Piperazineethanol (103-76-4) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-41-38 |
| Safety Statements | 26-36/39-37/39 |
| WGK Germany | 1 |
| RTECS | TL6825000 |
| Autoignition Temperature | 280 °C |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HS Code | 29335995 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Dam. 1
Skin Irrit. 2 |
| Toxicity | LD50 orally in Rabbit: 4000 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
1-(2-Hydroxyethyl)piperazine Usage And Synthesis
| Description | 1-(2-Hydroxyethyl)piperazine (HEP) is obtained during ethyleneamine production and used for corrosion inhibitors, pharmaceuticals, surfactants, and synthetic fibers.
|
| Chemical Properties | clear colorless to pale yellow oily liquid |
| Uses | 1-(2-Hydroxyethyl)piperazine is a hydroxyalkyl substituted pieprazine used in the preparation of pharmaceutical compounds such as neuroleptic agents. |
| Uses | 1-Piperazineethanol is a hydroxyalkyl substituted pieprazine used in the preparation of pharmaceutical compounds such as neuroleptic agents. |
| Flammability and Explosibility | Not classified |
1-(2-Hydroxyethyl)piperazine Preparation Products And Raw materials
| Raw materials | PIPERAZINE HEXAHYDRATE-->N,N-Bis(2-hydroxyethyl)ethylenediamine-->4-(2-HYDROXYETHYL)-PIPERAZIN-2-ONE-->Nornitrogen mustard-->TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE-->1-ALLYL-4-(2-HYDROXYETHYL)-PIPERAZINE-->1,4-BIS(2-HYDROXYETHYL)PIPERAZINE-->ETHYLENE OXIDE-->2-Bromoethanol-->Piperazine-->GLYCOLALDEHYDE-->Triethanolamine-->N-(2-Hydroxyethyl)glycine |
| Preparation Products | Manidipine-->ACETOPHENAZINE MALEATE (200 MG)-->1-(2-Hydroxyethyl)-4-methylpiperazine-->Triethylenediamine-->1-Ethylpiperazine-->2-(4-Benzhydrylpiperazino)ethyl acetoacetate |
