1,10-Phenanthroline hydrate CAS 5144-89-8
Introduction：Basic information about 1,10-Phenanthroline hydrate CAS 5144-89-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1,10-Phenanthroline hydrate Basic information
| Product Name: | 1,10-Phenanthroline hydrate |
| Synonyms: | 1,10-PHENANTHROLINE H2O;1,10-Phenanthroline monohydrate, reagent ACS;1,10-Phenanthrolinemonhydrate;1,10-Phenanthroline monohydrate, ACS;1,10-Phenanthroline, ACS, 99%;1,10-PHENANTHROLINE MONOHYDRATE extrapure AR;1,10-Phenanthroline, Monohydrate, Reagent;1,10-Phenanthroline Monohydrate [for Biochemical Research] |
| CAS: | 5144-89-8 |
| MF: | C12H8N2.H2O |
| MW: | 198.22 |
| EINECS: | 627-114-9 |
| Product Categories: | Miscellaneous;Analytical Chemistry;Chelating Reagents;Environmentally-friendly Oxidation;Ligands (Environmentally-friendly Oxidation);Phenanthrolines;Synthetic Organic Chemistry;ACS Grade;Analytical Reagents;Analytical/Chromatography;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;Essential Chemicals;Heterocyclic Building Blocks;Indicators;Inorganic Salts;N-Containing;Others;P;Redox Indicators;Research Essentials;Solutions and Reagents;Titration;bc0001;5144-89-8 |
| Mol File: | 5144-89-8.mol |
1,10-Phenanthroline hydrate Chemical Properties
| Melting point | 100-104 °C(lit.) |
| Boiling point | 365.1° |
| bulk density | 300kg/m3 |
| density | 1.10 |
| vapor density | 6.2 (vs air) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: soluble200MM (Stock solution is stable for months at –20° C.) |
| form | Needle-Like Crystals |
| color | Off-white, may become cream-colored during storage |
| biological source | synthetic (organic) |
| Water Solubility | <0.01 g/100 mL at 21 ºC |
| Merck | 14,7214 |
| BRN | 4008096 |
| Stability: | Stable. Incompatible with iron, other heavy metals, strong oxidizing agents, strong acids. |
| InChI | 1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2 |
| InChIKey | PPQJCISYYXZCAE-UHFFFAOYSA-N |
| SMILES | O.c1cnc2c(c1)ccc3cccnc23 |
| CAS DataBase Reference | 5144-89-8(CAS DataBase Reference) |
| EPA Substance Registry System | 1,10-Phenanthroline, monohydrate (5144-89-8) |
Safety Information
| Hazard Codes | T,N |
| Risk Statements | 25-50/53 |
| Safety Statements | 45-60-61 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | SF8437000 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29339990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 |
| Toxicity | LD50 orally in Rabbit: 132 mg/kg |
| Chemical Properties | white crystals or powder |
| Uses | 1,10-Phenanthroline monohydrate is useful to study the DNA-protein interactions due to its nuclease activity. It is used as a redox indicator and reagent for spectrophotometric assay of silver. It acts as a chelating ligand for the determination of Fe, Pd and V. It also acts as a matrix metalloproteinase inhibitor. It is a photometric reagent for iron, which forms a red chelate with ferrous (iron II) ion. |
| Uses | When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions. 1,10-Phenanthroline monohydrate is an aromatic nitrogen heterocycle that may be used as a chelating agent in the preparation of metal-chelate complexes. |
| General Description | White crystalline powder or solid. Slight odor. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | 1,10-Phenanthroline hydrate is incompatible with strong oxidizers. 1,10-Phenanthroline hydrate is also incompatible with strong acids. 1,10-Phenanthroline hydrate forms complex compounds with ferrous ions. . |
| Fire Hazard | Flash point data for 1,10-Phenanthroline hydrate are not available. 1,10-Phenanthroline hydrate is probably combustible. |
| Biochem/physiol Actions | Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM. |
| Purification Methods | Crystallise its picrate (m 191o) from EtOH; then the free base is liberated with aqueous alkali, dried at 78o/8mm over P2O5 and crystallised from pet ether (b 80-100o). [Cumper et al. J Chem Soc 1188 1962.] It can be purified by zone melting. It has also been crystallised from hexane, *benzene/pet ether (b 40-60o) or sodium-dried *benzene, dried and stored over H2SO4. The monohydrate is obtained by crystallisation from aqueous EtOH or ethyl acetate. It has been crystallised from H2O (300 parts) to give the monohydrate m 102-103o which sublimes at 10-3mm [Fielding & LeFevre J Chem Soc 1811 1951.] The anhydrous compound has m 118o (after drying at high vacuum at 80o) and is also obtained by recrystallisation from pet ether or *C6H6 (70 parts) and drying at 78o/8mm. [UV: Badger et al. J Chem Soc 3199 1951.] IthasapKainH2Oof 4.857 (25o) or 5.02 (20o) and 4.27 in 50% aqueous EtOH (20o). [Albert et al. J Chem Soc 2240 1948]. [Beilstein 23 H 227, 23 II 235, 23/8 V 419.] |
1,10-Phenanthroline hydrate Preparation Products And Raw materials
| Preparation Products | 4-Vinylcyclohexene dioxide-->1 10-PHENANTHROLINE-5 6-DIONE 97-->2,9-Dichloro-1,10-phenanthroline-->N,N'-TRIMETHYLENE-1,10-*PHENANTHROLINIUM DIBROMIDE |
