Introduction：Basic information about 1-Hydroxy anthraquinone CAS 129-43-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1-Hydroxy anthraquinone Basic information
| Product Name: | 1-Hydroxy anthraquinone |
| Synonyms: | 4-HYDROXYANTHRAQUINONE;1-hydroxy-9,10-anthracenedione;1-HYDROXYANTHRAQUINONE;erythroxyanthraquinone;1-hydroxyanthracene-9,10-dione;NISTC129431;10-Anthracenedione,1-hydroxy-9;1-hydroxy-10-anthracenedione |
| CAS: | 129-43-1 |
| MF: | C14H8O3 |
| MW: | 224.21 |
| EINECS: | 204-946-7 |
| Product Categories: | Anthraquinones;Hydroxyanthraquinones;Classes of Metal Compounds;Li (Lithium) Compounds;Typical Metal Compounds |
| Mol File: | 129-43-1.mol |
|
1-Hydroxy anthraquinone Chemical Properties
| Melting point | 194°C |
| Boiling point | 325.61°C (rough estimate) |
| density | 1.2337 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform: 30 mg/ml |
| pka | 7.15±0.20(Predicted) |
| form | powder to crystal |
| color | Light yellow to Brown |
| InChI | 1S/C14H8O3/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7,15H |
| InChIKey | BTLXPCBPYBNQNR-UHFFFAOYSA-N |
| SMILES | Oc1cccc2C(=O)c3ccccc3C(=O)c12 |
| CAS DataBase Reference | 129-43-1(CAS DataBase Reference) |
| IARC | 2B (Vol. 82) 2002 |
| NIST Chemistry Reference | 9,10-Anthracenedione, 1-hydroxy-(129-43-1) |
| EPA Substance Registry System | 9,10-Anthracenedione, 1-hydroxy- (129-43-1) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-40-36 |
| Safety Statements | 26-36/37/39-45 |
| WGK Germany | WGK 3 |
| RTECS | CB7178000 |
| TSCA | TSCA listed |
| HS Code | 2914.69.9000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Carc. 2
Eye Irrit. 2 |
| Hazardous Substances Data | 129-43-1(Hazardous Substances Data) |
1-Hydroxy anthraquinone Usage And Synthesis
| Uses | 1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1]. |
| Definition | ChEBI: 1-hydroxyanthraquinone is a monohydroxyanthraquinone. |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 55, p. 350, 1990 DOI: 10.1021/jo00288a062 |
| in vivo | 1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1]. | Animal Model: | Thirty rats[1]. | | Dosage: | 1% HA in diet. | | Administration: | Diet. | | Result: | Associated with decreased weight gain which was particularly marked towards the termination of experiment.
One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment.
A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon.
Seven animals of the group died spontaneously or were sacrificed upon becomingmoribund between 335 and 462 days.
A total of 21 rats of group 1 survived until the end of experiment (mean value of totalintake of HA/rat was 76.8 g).
|
|
| References | [1] H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802. DOI:10.1093/carcin/11.5.799 |
1-Hydroxy anthraquinone Preparation Products And Raw materials
| Raw materials | 1-NITROANTHRAQUINONE-->Alizarin-->1,4-Dihydroxyanthraquinone-->1-AMINO-2-METHYLANTHRAQUINONE |
| Preparation Products | 1-Aminoanthraquinone-->2-HYDROXYANTHRAQUINONE-->1,4-Dihydroxyanthraquinone |
