Introduction：Basic information about 1-Hydroxy-2-naphthoic acid CAS 86-48-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1-Hydroxy-2-naphthoic acid Basic information
| Product Name: | 1-Hydroxy-2-naphthoic acid |
| Synonyms: | LABOTEST-BB LT00452757;RARECHEM AL BE 0359;Salmeterol Hydroxynaphthoic Acid Impurity (USP);ALPHA-HYDROXYNAPHTHOIC ACID;1-NAPHTHOL-2-CARBOXYLIC ACID;1-HYDROXY-2-NAPHTHOIC ACID;1-HYDROXY-NAPHTHALENE-2-CARBONIC ACID;1-Hydroxy-2-phthoic acid |
| CAS: | 86-48-6 |
| MF: | C11H8O3 |
| MW: | 188.18 |
| EINECS: | 201-674-0 |
| Product Categories: | Aromatics;Intermediates of Dyes and Pigments;bc0001 |
| Mol File: | 86-48-6.mol |
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1-Hydroxy-2-naphthoic acid Chemical Properties
| Melting point | 195-200 °C (dec.) (lit.) |
| Boiling point | 283.17°C (rough estimate) |
| density | 1.2100 (rough estimate) |
| refractive index | 1.6310 (estimate) |
| Fp | 150 °C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | alcohol: freely soluble |
| pka | 3.02±0.30(Predicted) |
| form | Powder or Crystals |
| color | White to slightly pink to tan |
| Water Solubility | SOLUBLE IN HOT WATER |
| Merck | 14,4834 |
| BRN | 974438 |
| InChI | 1S/C11H8O3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H,(H,13,14) |
| InChIKey | SJJCQDRGABAVBB-UHFFFAOYSA-N |
| SMILES | OC(=O)c1ccc2ccccc2c1O |
| LogP | 3.196 (est) |
| CAS DataBase Reference | 86-48-6(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Hydroxy-2-naphthoic acid (86-48-6) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39-37 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 29182910 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
1-Hydroxy-2-naphthoic acid Usage And Synthesis
| Chemical Properties | beige to brown-grey powder. 1-Hydroxy-2-naphthoic acid [86-48-6],C11H8O3, Mr 188.17, mp 200℃, is only sparingly soluble in hot water but readily soluble inalkali and ethanol. It couples with diazo compounds in the 4-position and, with excess, in the4,7-positions. It is sulfonated by oleum to givethe 4-sulfonic and then the 4,7-disulfonic acids.Halogenation occurs in the 4-position, and nitrosation gives 2-nitroso-1-naphthol. |
| Uses | Metabolite from phenanthrene degradation. 1-Hydroxy-2-naphthoic acid is used as an intermediate for azo and triphenylmethane dyes and, more recently, for color-film dyes. |
| Uses | It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff. |
| Definition | ChEBI: 1-hydroxy-2-naphthoic acid is a naphthoic acid with the carboxy group at position 2 and carrying a hydroxy substituent at the 1-position. It is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms. It has a role as a bacterial xenobiotic metabolite and a fungal xenobiotic metabolite. It is a naphthoic acid, a member of naphthols and a hydroxy monocarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a 1-hydroxy-2-naphthoate. |
| Preparation | Treatment of the dried sodium salt of 1-naphthol with carbon dioxide at 135℃ under pressure gives an 80 % yield of product. |
| General Description | 1-Hydroxy-2-naphthoic acid is produced by the transformation of phenanthrene by NCIB 9816 clones. |
| Purification Methods | Successively crystallise the acid from EtOH/water, diethyl ether and acetonitrile, with filtration through a column of charcoal and Celite. [Tong & Glesmann J Am Chem Soc 79 583 1957, Beilstein 10 H 331, 10 IV 1194.] |
1-Hydroxy-2-naphthoic acid Preparation Products And Raw materials
| Raw materials | Carbon dioxide-->Water-->1-Naphthol-->Sodium formate-->1-Naphthalenol, sodium salt-->MAGNESIUM METHYL CARBONATE-->Potassium bicarbonate |
| Preparation Products | 2-hydroxymethyl-1-naphthol-->1-HYDROXY-2-NAPHTHALDEHYDE-->4-Hydroxy-1-naphthoic acid-->2-Nitroso-1-naphthol-->NAPHTHOCHROME GREEN-->4-[Bis[4-hydroxy-3-(sodiooxycarbonyl)-1-naphthalenyl]methylene]-1,4-dihydro-1-oxonaphthalene-2-carboxylic acid sodium salt-->1,7-dihydroxynaphthalene-2-carboxylic Acid |
