1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione CAS 6812-87-
Introduction：Basic information about 1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione CAS 6812-87-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione Basic information
| Product Name: | 1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione |
| Synonyms: | 1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione;(4bS)-2-Isopropyl-3-hydroxy-4bα,8,8-trimethyl-4b,5,6,7,8,8aβ,9,10-octahydrophenanthrene-1,4-dione;(4bS,8aS)-4b,5,6,7,8,8a,9,10-Octahydro-3-hydroxy-4b,8,8-trimethyl-2-isopropyl-1,4-phenanthrenedione;12-Hydroxyabieta-8,12-diene-11,14-dione;12-Hydroxy-13-isopropylpodocarpa-8,12-diene-11,14-dione;NSC 122417;1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-;(4bS,8aS)-3-hydroxy-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-1,4-dione |
| CAS: | 6812-87-9 |
| MF: | C20H28O3 |
| MW: | 316.43 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 6812-87-9.mol |
1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione Chemical Properties
| Melting point | 181.5-183.0 °C(Solv: acetic acid (64-19-7)) |
| Boiling point | 426.4±45.0 °C(Predicted) |
| density | 1.12±0.1 g/cm3(Predicted) |
| pka | 4.50±1.00(Predicted) |
Safety Information
| Uses | Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1]. |
| Definition | ChEBI: Royleanone is a diterpenoid. |
| References | [1] Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. PMID:30358211 |
1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione Preparation Products And Raw materials
